2()5 
CONCERNING THE TREATMENT OF 
EXPERIMENTAL TRYPANOSOMIASIS* 
PART II 
HY 
BENJAMIN MOORE, M.A., D.Sc., 
JOHNSTON PROFESSOR OF BlO-CHEMlSTRY 
M. NIERENSTEIN, Ph.D., 
I. W. GARRETT INTERNATIONAL FELLOW, ANU RESEARCH UEMONSl RATOR, LIVERPOOL 
SCHOOL OF TROPICAL MEDICINE 
AND 
JOHN L. TODD, M.D.. 
ASSOCIATE PROFESSOR OF PARASITOLOGY, MCGILL UNIVERSITY 
From the Rmworn Research Laboratories of the Liverpool School of 
Tropical yiedicine 
{Received for publication 14 f 
INDKX 
. . , . . 2DD 
I . Introduction . 
II. Completion of Part I . 
III. Inefficacious substances . 
IV. Aniline colouring matters . T ." j ” 
V. The therapeutic values of Atoxyl and acetylated Atoxyl 
compared . '' 
A. Dogs. -72 
1. Treatment by Atoxyl alone . ' 
2. Treatment by acetylated Atoxyl r, ■"iHp'nf 
3. Treatment by acetylated Atoxyl and bichloride of 
Mercury . 
H. Guinea Pigs. 274 
1. Treatment by Atoxyl alone .. V 'U:.i'' hU 
2. Treatment by acetylated Atoxyl followed by 
bichloride of Mercury . ■‘/a 
VI. Treatment by Atoxyl followed by j 'vrlV/^iirv ii-r 
VII. Treatment by Atoxyl followed by bichloride of Mercury 277 
A 
1. Controls, treated by Atoxyl alone 
2. Treatment by Atoxyl followed by bichloride of 
Mercury . ..,•. 
(a) Infections with Trypanosoma brucet . ^7/ 
(i) Infection.s with Trypanosoma gambiense . 79 
B. Donkeys. , , ,80 
1. Controls, treated by Atoxyl alp^e 
2. Treatment by Atoxyl followed by bichloride of 
Mercury . 282 
(0) Symptomatic treatment . „ 
(i) Routine treatment .. . 
VIII. Treatment by Trypanroth followed by bichloride of 
,,, Mercury .. 286 
*A, Summary and conclusions . . . 
, * Grants in aid of this work were received by us gratefullv 
of us (Xierensteinl from the British Medical Association, we g 
acknowledge the assistance received from these bodies. Atoxyl (Acetyl- 
Our thanks are also due to Professor Ehrlich xj-cLe Baver and Co., 
Kl®*™'no.phenyl.arsenic acid, 8 and n); and ‘ which we report in 
Wberfeld. Germany, for the various colouring matters on wnicn f 
Action IV, 
T 
