oaibe twelfth day; a ihiid dose of the -same solution of At.jxyl was then given, 
bnt^ath followed on the founeenth day of the experiment although the parasites 
were not seen. 
EmEiitEST 4.,h—Trypano 5 ome> aiipeared in the blood on 
On the fifth and again on the sixth day a dose of 3 c-c'"- ^ ^ ® n lhsent’ 
sohUon of Atoxvl was given. The trypanosomes disappeared and remained absent. 
bm death followed on the tenth day of the experiment. 
Eipebiment 437.-Trypanosomes appeared in the peripheral circulation on the 
fourth day; a dose of 3 c.cm of a 5 per cent, solution of Atoxyl 
fifth day and on the sixth. The parasites disappeared and remained absent but 
the animal died on the ninth day. 
From these five experiments it may be concluded that dogs 
infected with the strain of Trypanosoma bruui employed would die, 
though treated by Atoxyl, in about nine days. 
2. Treatment by acetylated Atoxyl alone. 
Expebimekt 4.6.-Trypanosomes appeared in the peripheral 
on the fourth day On the fifth day 5 c.cm. of a two per 
acetylated Atoxyl was given. The trypanosomes did not d^^sappear so th s dose wa>. 
repeated on the seventh day; it was again repeated on the twelfth day, 
although the parasites had disappeared after t e secon ^ ' ■ 
reappeared on the thirtieth day; two doses, each of 5 cxm. o oarasites 
solution were therefore given on the thirtieth and thirtyfitst ^^nh 
disappeared after the last of these doses and did not reappear until 
day, when two doses, each of S c.cm. of a three per cent. more o^tre 
successive days and the parasites disappeared, to reappea 
fifty-sixth day. In spite of another dose then given o 5 c-c 1. 
cent, solution, the animal died on the following day. Rats submoculated on the 
fifteenth and thirty-seventh days remained negative hprame 
A rat subinocilated on the fifty-first day, five days before deat^i, became 
ixfnUd, however, after a prolonged incubation period of eleven days and died 
four days later. 
Experiment 4i9.-Trypanosomes appeared in the peripheral circulation on the 
fourth day. On the fifth and again on the sixth day a dose 5 c.cm. of a w 
cent, solution of acetylated Atoxyl was given. The ^ 
recurred on the eleventh day when two more dose.s, each 0 5 • 
solution were administered ; although the parasites again disappeared, the g 
died on the eighteenth day after inoculation. , . , j 
Two dogs treated by acetylated Atoxyl alone lived eighteen an 
fifty-seven days. 
3. Treatment by acetylated Atoxyl followed by bichloride 
of Mercury. 
Experiment 334.-Trypanosomes appeared m blood on the second day 
after inoculation. On the third, fourth and fifth days ^^ree doses of 
ten per cent, solution of acetylated Atoxyl were given; on 
days two doses of loc.cm. of the sam^ solution Merc^rJ 
«ghth, the ninth and the tenth days 2 c.cm. of a one per c ^ 
bichlotid, wer. injected, and on the eleventh day were followed by a 
