•275 
2. Treatment by acelylaled Atoxyl followed by bichloride 
of Mercury. 
Expeument 407b.—Trypanosomes appeared in the blood on the sixth day. 
On the tveifth, thirteenth, twenty-second and twenty-third days, doses of I’S c.cm. 
of five per cent, solution of acetylated Atoxyl were given. These were followed on 
the twenty-fourth, twenty-fifth and twenty-sixth days by o'sc.cm. of a two per 
cent, solution of bichloride of Mercury. The animal died on the twenty-seventh 
day. No trypanosomes had been seen in the blood since the first dose of Atoxyl. 
Eipbeiue.vt 407c.—Trypanosomes appeared in the blood on the eighth day. 
Od the twelfth and thirteenth days 2 c.cra. of a five per cent, solution of acetylated 
.Motyl were given and were immediately followed on the two succeeding days by 
doses of ic.cm. of a two per cent, solution of Mercury bichloride. The parasites 
disappeared after the first dose of Atoxyl and did not reappear, but the animal 
died on the sixteenth day 
Expehmext 414a.— Trypanosomes appeared in the blood on the eighth day. 
On the tenth, eleventh, and twelfth days, doses of 1-5 c.cm. of a five per cent, 
solution of acetylated Atoxyl were given. These were followed on the thirteenth, 
fourteenth, fifteenth, and sixteenth days by doses of o’5 c.cm. of a two per cent, 
solution of Mercury bichloride, and on the seventeenth and eighteenth days by 
3-5 c.cm. of the same solution of acetylated Atoxyl in two doses, and, finally, on the 
nineteenth and twentieth days, by two doses of 1 c.cm. of the .same solution of 
Mercury bichloride. The trypanosomes disappeared from the blood on the second 
day of treatment and were still absent at the death of the animal from pneumonia 
on the sixty-seventh day. 
Hats were snbinoculated on the fourteenth, fortieth, and fifty-fourth days of 
die experiment; none of them ever became infected. 
Experimkxt 414. — Trypanosomes appeared on the third day. Treatment was 
commenced on the eleventh day by five consecutive daily doses of 1-5 c.cm. of a 
per cent, solution of acetylated Atoxyl. These were followed on the seventeenth 
and eighteenth days by two doses of 0-5 c.cm. of a two per cent, solution of 
bichloride of Mercury. The parasites disappear'fed from the blood on the second 
day of treatment and remained absent, but the animal died on the nineteenth day. 
Experiment 419. — Trypanosomes appeared in the blood on the eighth day- 
frealment was commenced on the thirteenth day with three consecutive doses of 
'■5 c.cm. of a five per cent, solution of acetylated Atoxyl. It wa.s continued on the 
twentieth and twenty-first days by two doses of 2 c.cm. of the same solution of 
Atoxyl, followed on the three next days by daily doses of 0*5 c.cra. of a two per 
cent, solution of Mercury bichloride, and on the twenty-sixth day by one more dose 
2 c.cm. of Atoxyl. The parasites which had disappeared from the blood on the 
^ond day of treatment remained absent until the forty-fifth day. On their 
teappearance their treatment was resumed by four consecutive daily doses of 
2 c.cm. of the same solution of Atoxyl; these were followed on the fiftieth day by 
• c.cm. of a two per cent, solution of Mercury bichloride. The animal died on the 
next day, trypanosomes being ab.sent from its blood. 
Five g;uinea pigs treated by acetylated Atoxyl and bichloride of 
Mercury died in from sixteen to sixty-seven days (average about 
thirty days). 
