276 
C. Mice. 
Only one experiment was made, with the object of comparing the 
relative therapeutic values of AtoxyJ and acetylated Atoxyl. 
KxPEHnjENT 443. — Two lots of three mice each were inoculated with 
approximately equal amounts of infected blood from a common source. .Allbecamr 
infected on the third and fourth days. Kach animal on the day it was foimd to 
be infected was treated; three mice received Atoxyl, and three acetylated Aloiyl 
(approximately equal quantities of the drug were given). Those treated with 
Atoxyl died on the fourth and fifth days; those with acetylated Atoi)l on the 
ninth and eleventh clays. 
From these experiments, so far as they permit comparisons and 
conclusions, we deduce for tlie animals concerned, that:— 
Treatment by acetylated Atoxyl followed by Mercur)' is more 
efficacious than is treatment by acetylated Ato.xyl alone; acetylated 
Atoxyl is of more value than Atoxyl; but that none of these methods 
is of practical value since death invariably occurred.* 
VI. TREATMENT BY ATOXYL FOLLOWED BY ANOTHER DRUG 
As explained in our former paper, it was thought that substances, 
ordinarily without therapeutic value, might be trypanocidal when 
administered after Atoxyl; it was this line of work which led to the 
discovery of the efficacy of Atoxyl combined with bichloride of 
Mercury in the treatment of trypanosome-infected rats. 
The following combinations were tried and found to be valueless; 
the parasites generally reappeared in the blood in from three to four 
weeks after the cessation of treatment, and death followed in due 
course. 
Atoxyl and Silver Nitrate. 
Atoxyl and Lead Acetate. 
Atoxyl and Quinine-cacodylate. 
Atoxyl and Potassium Bichromate. 
Atoxyl and Quinine. 
or direct ^ypanosoines could not be detected, either by subinoculalion 
and it must he these animals for many days before their death, 
cause intoxication really died of trypanosomiasis or from some other 
norobleJveT tL sam example 7 gross signs of overdosage were 
# 
