277 
VII, TREATMENT OF ATOXYL FOLLOWED BY BICHLORIDE OF 
MERCURY 
Under this heading are reported our attempts to apply the 
combined use of Atoxyl and bichloride of Mercury, found successful 
m the treatment of rats, to the cure of large animals infected with 
tr)-panosome5. Rabbits and donkeys were used in this series ot 
experiments. 
A. Rabbits. 
I. Controls, treated by Atoxyl alone. 
Three control rabbits which only received the same amount of 
Atoxyl as was used in the combined treatment by Atoxyl and 
bichloride of Mercury, all died in about fifty-five days after 
tion. In one rabbit (Experiment 302) death also occurred, 
the dosage by Atoxyl was re|3eated continuously. n a , 
infecting trypanosome was 7 rypanosoma briicei. 
Expebimest 30j.-Fourtee>i days after *On fhe'^first day ^ c.cm. of a 
the blood. Treatment was commenced nine days another dose of i c.cm. 
S.. p„ cent, solulian of Afo,yl was given , ona then 
was injected, and on the day following 2 c.cm. ^ 
repealed for ten times at intervals of ^L^o^days to a rabbit weighing 
of Atoxyl solution weie given in twelve doses in fo y T-^nanosomes reappeared 
1805 grammes at the commencement of the commencement of treatment, 
in the peripheral blood in forty-three days after t 
and the animal died three days later weighing 156° grammes. 
Rabbits treated by Atoxyl alone, whether continuously or not. 
died in about fifty to sixty days after inoculation. 
2. Treatment bv Atoxyl followed by bichloride of Mercury. 
[a) Rabbits infected with Trypanosoma hrucet 
Experiment 288.— After fifteen days trypanosomes^appear^d^^ 
rabbit inoculated on January 7. bix days la ^.p;«ht of 21^0 grammes, 
animal had already lost no grammes of an origi during a 
Three c.cm. of a five per cent. Atoxyl 7®;® g^'dayr Three days after 
period of eleven days ; 2 c.cm. being S^en in th commenced, and 
the last dose of Atoxvl the dosage by bichlori hinnH was examined daily 
4 c.cm. in four doses'were given in five daysMime. died, 
br one hundred and forty-seven days, until tiere were no signs of 
No macroscopic cause of death was seen at t e au P F ’ treatment 
trypanosomiasis. Mice were subinoculated from t is an hundred and forty-one 
was stopped and at fourteen, twenty-five, fifty-one ai (with 10 c.cm. of 
(3 mice! days from that date. A young puppy carefully observed for a 
Wood, a, the time of the eutopsy. All these ammalsjere -refuBy 
sufficient length of time; none of ®^ after the first dose of Atoxyl 
trypanosomes. A rat inoculated on the third day after the 
became infected in nine days and died three days a 
