28 i 
of the trypanosomes, which had disappeared after the first 
parasites then again left the blood, only to reappear on the forty-first day. Death 
followed on the forty-sixth day. 
ExPEiiUEXT 391.—Trypanosomes appeared in the blood ou the fifth day af er 
moculation. On the thirty-first day treatment was commenced by ^ ^ose o 
.oc.cm. of a ten per cent, solution of Atoxyl. This was repeated, as ^be parasites 
reappeared in the blood, on the thirty-second, thirty-third, thirty-eighth, fo y 
JnTInd forty.fifth days. Since the last dose of Atoxyl did not drive out the 
trypanosomes, a dose of aoc.cm. of a twenty per cent, solution of 
givk The parasites disappeared then from the blood, but the animal died three 
days later on the forty-eighth day- 
Experiuest 393. —Trypanosomes appeared in the blood on the dailv 
Treatment was commenced on the thirty-fifth day by giving four 
d^esofioc-cm. of a ten per cent, solution of Atoxyl. The parasites 
from the blood, only to reappear on the forty-sixth day, w en lo . 
p..«. of A.o,yrwas given. The parasites once 
return again on the fifty-eighth day, when a dose of aoc.cm. o a - b^god 
solution of Atoxyl was given. The parasites again gub- 
and did not return before death on the sixty-seventh day. -r^h davs 
inoculated from this animal on the thirty-seventh, six^- rs an si carefullv 
when trypanosomes were not present. All three of these animals 
eraminrffor periods of from three to four months; none of them ever became 
Experiment 2.—Trypanosomes appeared in the bloofl Jbe fo 
Treatment was commenced on the thirty-fourth day ^ ^ following days and 
solution of Atoxyl. This dose was repeated daily on the thre g ^ 
again, when Jce that amount was given, on f-ty. our^ 
trypano-somes. which had been absent since the seco r 
forty-seventh day and the animal, in spite of a dose ° i^ted on the 
solution of ‘Afridol,’ died on the day following. Rats suDinocui 
thirty-sixth and forty-sixth days never became infected. 
Experiment 393.— Trypanosomes appeared the ^ ® ^ . giving 
Treatment was commenced on the twenty-sixth and two careful 
daily 10 c.cm. of a ten per cent, solution of Atoxyl. In did 
nursing, the animal died on the thirty-seventh day. bough t yi . j 
not reappear in the peripheral blood. Two rats subinoculated on the 
day of the experiment never became infected. Hav 
Experiment 17.—Trypanosomes appeared bloo o^'Atoxyl. 
Treatment consisted of 10 c.cm. of a ten per ^ , thereafter, once a 
the twenty-second, twenty-seventh and twenty-eight , ’ -^be trypanosomes 
week until the death of the animal on ^be "inety-seventh v. ^ not 
disappeared from the blood immediately after the rs -when thev again dis- 
«appear until the seventy-eighth .5 nf^alshows a typical high 
appeared and were absent at death. The chart 0 • teraoerature remained 
fever until the commencement of treatment : dav. when it again 
approximately normal with slight rises until the 
W™,high-acd continued to run an Mn„d on the thi.d 
Experiment 19.—Trypanosomes appeared in * P ' 10 c.cm. of a 
day. Treatment was commenced on ^be twenty-fourth dav.jv^en^^^^^ ^ 
ten per cent, solution of Atoxyl was given. . 1 ttn» seventy-third day. 
^tmd day from that time until the death of the Atoxyl. Rats 
T^ncomea were not aeen in the blood after * Lwever, 
'nocnlated on the twentv-fifth and thirty-eighth and died in due 
W after a prolonged incubation of about two weeks 
U 
