323 
COMPARATIVE 
CHEMO-PHERAPEUriCAL STUDY OF 
ATOXYL AND TRYPANOCIDES 
PART II 
BY 
M. NIERENSTEIN, Ph.D., 
I. W. GARMTT IKTERNATIOSAL FELLOW AND RESEARCH PEMONSTRATOR, 
LIVERPOOL SCHOOL OF TROPICAL MEDHTNE 
W, the Runcorn Research Laboratories of the Liverpool School 
of Tropical Medicine 
(Received for publication cj December, igo 8 ) 
Our previous worki on the chemo-therapeutics of Atoxyl has led 
JSto the conclusion that a combination in vitro takes place 
.rotems, and Atoxyl mono-acetylated Atoxyl and morro-benaoylated 
Atoxyl respectively; whilst, on the other hand, such a 
does not occur between proteins, and sodmm arsOTUte ““ J 
Atoxyl and sodiiira-p-hydroxy-phenyEa.tsenate. us wor . , i 
continued by injecting the above-mentioned drugs into 
animals ; these reacting in an analogous way to the seni p 
. with only one exception-acetyl-ben.oyl AtoxyE^ 
combined with the serum proteins m vvvo. This reac 
was only to be expected, as the organism saponifies the ace y g 
and the resulting benzoyl Atoxyl ads m the same way 
weekly, with Atoxyl, Sodmm """"hN^drlxyl-phenyl-arsenate. 
Atoxyl, Benzoyl-acetyl Atoxyl, and Sodium-h>dro. y P 
L-Jly , C.C. of . per cent, solution of the drug wms ^ 
After a time, 20 c.c. of blood was taken from the jugular 
the scrum used for analysis. previous 
The arsenic was estimated in the same ^ aaooted Gold 
work ; the slightly modified Sanger s met o . -ujoric acid, 
chloride was used as developer in preference to y - 
The results of the experiments are given m the 
