and later gave rise to recurrences of trypanosomes more or less 
refractory to Atoxyl treatment.’ The Atoxyl was, therefore, 
followed by a second drug; tire best results, experimentally, were 
obtained by using mercury salts, after the disappearance of the 
parasites from the peripheral circulation lind been brought about by 
Atoxy'l. In small animals, such as ruts and rabbits, infected with 
T. brucei, the results were far superior to treatment by Atoxyl alone; 
in large animals, as donkeys, on the other hand, the combined treat¬ 
ment with Atoxyl and Mercury was not found to be efficacious 
enough to be of practical value. 
Plimmer and Thomson^ repeated the experiments on rats infected 
with Surra and Ngana, obtaining similar results to those of Moore 
Nierenstein and Todd, but using different mercury siilts. In their 
hands the combination of Atoxyl and Succinamidc of Mercury gave 
the best results. In a further communication,^ however, they state 
that, in small animals at any rate, Mercury has not given altogether 
satisfactory results, wliich fact they attribute to tlie small doses of 
Mercury'. On enlarging the doses of Mercury', chronic kidney, and, 
to a lesser degree, liver lesions, were observed. They conclude, 
therefore, that more favourable results migdit be obtained in dealing 
with a more chronic trypanosome disease, such as Sleeping Sickness 
in man. 
Laveran's and T]iiroux’s« observations on the combined treat¬ 
ment of Atoxyl and Bichloride of Mercury on Surra in guinea-pigs 
are. although not very good, suiierior to the treatment by Atoxyl 
alone. . 
According to Uhlenhutli, Hiibncr nnd Woitlie,-" the combined 
treatment on rats infected with Donrine was of considerable value, 
isin„ ^a\erans and I hironx's e.vpcrinients, they remark that 
'ir'Tb ■ ^ treatment in general does not give good 
results, this being due to the fact that these animals verv often die 
The“ -son. 
and M ” obtained by the combined treatment of Ato.vyl 
nd Mercury in experimental animals, justified its use in human 
■^'^^-Saticn C-amps for the medical treat- 
trSa Sleeping Sickness in Uganda, gave this method a thorough 
Mercury was adniinistered 
in different fornis and at different 
