The method of treatment according to ‘ improved cases is, 
therefore: 
— 
1. 
Method (A), 64 per cent. . 
II. 
Method O'). 58 per cent. 
- Atoxyl and Mercurt’ 
1 
HI. 
Method (^), 39 per cent. , 
IV. 
Method O'). 34'5 cent.! 
1 
V. 
Method {b), 34 l»er cent. 
1 
VI. 
Method {b). 33 per cent. 
Atoxyl alone. 
VII. 
Method (/), 10 i5cr cent. 
1 
Bohneio describes one case of trypanosome fever which improved 
markedly under the combined Atoxyl-Mercury treatment, but the 
time of observation is too short to conclude that this patient has be 
definitely cured. 
Broden and Rodhain," on the other hand, come to the coiiclusion 
that the combined treatment did not prove superior at 
treatment with Atoxyl alone. . 
As Moore’s, Nierenstein's and Todd's work was mostly carried out 
on animals infected with T. brucei, it seemed advisable to repe 
work on monkeys infected with T. gawbiense. Six anima 
[Cmotitlmus callithricus) were inoculated with our =^boratory 
strain of T. gmMense, and after varying time subjected to , 
Acetylated Atoxyl, which, in former experiments, a prov 
less toxic than Atoxyl, was used. k oq gm was 
Experiment \.—Ctrcopiihccus callithruus, 2 . relapse, on 
inoculated on April 28th with T. gambttnse. shown typical signs of the 
June ,st. treatment was begun after the an.ma gm. in weight. 
infection ; the animal was markedly of acetylated Atoxyl was given. The 
On June ist and and, an injection of o i gm. y Atoxyl 
parasites disappeared after the Hrst Sublimate. On July and 
was followed by an intra-muscular injection o 5 s injections of 
and 3rd. the Atoxyl injection, and on July J 5 of the blood were 
Sublimate were repeated. bLrexamined twice weekly. No 
made, and since then the peripheral blood has injection. The blood 
trypanosomes have been seen since June ist, . jn weight to ak. 845 S*" ' 
count is normal (March 7th). The animal has inc Kovember. 
which has been maintained with slight vana 10 weight a k. 700 
Experiment U.—CercofilhecHS callitbruus, ’ never showed parasites 
inoculated on April 28th with T. gambitnse. as the symptoms of the 
in great number. On June 16th, treatment was b g o.i gm. of 
disease became more and more marked. were followed on June «t 
acetylated Atoxyl was administered; these inje gluteal region. The 
and ,9th by 0-05 gm. of Sublimate. oaralysis of the hind leg. 
tajection of Sublimat. waa followed by complete para y 
