produced a harmful effect. The doses which proved perfectly harmless in the 
foreeoing experiments caused the whole complex of symptoms of a typical Atoxyl 
poisouing. Tremors occurred all over the body, and, at the same time, a severe 
slimy diarrhoea started. These symptoms, however, passed off in the course of a 
week. On Tune 26th and 27th, injections of 1 c.c. of Donovan’s solution was given. 
This animal is sUll alive, weighing at present 3 k. xoo gm. The blood is normal; 
parasites have never been seen since treatment was begun. 
The foregoing experiments show that in five cases out of six, 
the administration of Acetylated Atoxyl and Sublimate, and 
Donovan’s solution, in monkeys {Cercopithecus caHithricus), has 
effected a complete cure. 
If we consider that in our experiments Cercopitheciis calhthrtcus 
usually succumb to an infection of T. gambicnse in the course of 
40-60 days, the results of Atoxyl- Mercury treatment in monkeys 
infected with 7 . gambiense must be looked upon as very encouraging 
indeed. 
The length of time which has elapsed since treatment was 
discontinued is probably sufficient to permit of the anima s g 
considered as definitely cured of the disease. 
Concerning the action of the combined treatment by Atoxyl and 
Mercury, a conclusive opinion can hardly yet be expresse . > 
has proved beyond doubt to have not the least effect on trypanosomes 
in the peripheral circulation. It is, therefore, very tempting to p 
Moore’s, Nierenstein’s and Todd’s suggestion of its actio 
secondary resistant form of the parasite which it estr y , 
whether we accept this hypothesis or suppose that the Mercury 
merely as an internal disinfectant after the destruction 
parasites by Atoxyl, the success of the combined treatmen 
depend upon the administration of the two drugs eit er con 
or in rapid succession. 
