365 
THE ACTION OF ARYL-STIBINIC ACIDS 
IN EXPERIMENTAL TRYPANOSOMIASIS 
BY 
ANTON BREINL, 
ItIBF.CTOR Of THE Rl NCOBN RESEARCH LABORATORIES OK THE 
LIVERPOOL SCHOOL OF TROPICAL MEDICINE 
AND 
M. NIERENSTEIN, 
J.W. GARRETT INTERNATIONAL FELLOW, AND RESEARCH DEMONSTRATOR, LIVERPOOL 
SCHOOL OF TROPICAL MF.DICINE 
From (he Runcorn Research Laboratories of the Liverpool School of 
Tropical Medicine 
(Received for publication 3 April, 1909^ 
Plimmer’s and Thomson’s important discovery of the trypanocidal 
action of Antimony, an element chemically closely allied to Arsenic, 
was the starting point for extensive investigations on the value of 
different Antimony compounds in the treatment of Trypanosomiasis. 
In their first experiments' they used Potassium antimonyl tartrate, 
and observed that this drug destroyed the trypanosomes in the 
peripheral circulation more rapidly than Atoxyl. The injections 
caused neither pain nor inflammatory changes of the tissue. In their 
experiments, out of twenty-five rats only four showed recurrences; 
nine lived for over two hundred days, and nine considerably over o 
hundred days; the remaining three died without any ° 
Tiypanosomiasis, and in none were trypanosomes found after ^ ea 
Mesnil and Brimont^ were able to confirm Phmmers an 
Thomson’s observations concerning the powerful trypanoci a 
of Potassium antimonyl tartrate. Their experiments several 
strains of patbncrpnir trvnanosomes, however, prove t at a 
'njection the 
short time. 
observed, and the drug had always the same 
fhe animals died finally either with or 
••V £ 
transitory effect ; most ot 
without parasites after 
iliscontinuation of the treatment. Their results m 
'fith r. roansi, were more satisfactory ; and it is spe 
suits in animals infected 
it is specially noteworthy 
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