rhlenhuth and WoitheS repeated the experiments with Sodium 
antimonyl tartrate on twenty-seven rats infected with T. eqmperdum, 
but their results were as discouraging as those with Arsenious acid. 
Even repeated injections of 0-003-0-005 gramme of the Sodium salt 
and 0-002—0-003 gramme of the Potassium salt were unable to effect 
even temporary disappearance of the parasites from the blood. 
Broden and Rodhain^* used soluble as well as insoluble compounds 
of Antimony in Sleeping Sickness treatment. The hypodermic 
injections caused great irritation and pain, and were followed, even 
when given intramuscularly, by large swellings; this reaction 
persisting for some days, and only disappearing after one week^ 
Therefore, the drug was administered intravenously. A dose or 
ff07 gramme was sufficient in some cases to cause the parasites to 
disappear, but they very soon reappeared m the penphera 
circulation. These observers recommend a dose of 0*1 gramme ot 
Tartar emetic. This dose given intravenously did not usua y caus 
any severe symptoms; it was followed sometimes y p 
perspiration and vomiting. After repeated injections the patient 
usually lost their appetite and complained of genera ^a a 
interruption of the treatment these symptoms passe o . 
able to conHrm the rapidity of the destructive action Ant.mony 
the parasites, but remark that,' Ces constatat.ons dorvent nous tmpos 
une extreme reserve dans I'appreciatron de la valeur 1 ant.mom^ 
bans le traitement de la trypanosomiasis humaine et exig 
.. 1 -. 
Atoxyl treatment of Sleeping Sickness patients with m ec 
soluble Antimony compounds with very encouraging r c^nhilis are 
G- ““ 
recorded by P. Salmon,^^ and Broden an 
confirm the beneficial effect of Antimony m of 
Plimmer’s and Thomson’s ° the blood of infected 
Potassium antimonyl tartrate on trypano r^rcrinic Antimony 
animals seemed to justify an attempt to prepare „oorison of the 
compound analagous to Atoxyl. Atoxyl made it 
effects of injections of Sodium arsenate \vi 
