370 
B. Dogs. 
Two dogs were used for the experiments (see Table II). In 
experiment 245 the dog was treated with Sodium-amino-phenyl- 
stibinic acid ; in experiment 244 with the acetylated derivative of the 
same compound. In the former experiment severe abscesses resulted 
from the injections, and after a very short time the animal succumbed 
to the toxic effects of the drug. The post-mortem examination 
revealed a haemorrhagic nephritis. 
The subcutaneous injections of the acetylated compound, on the 
other hand, did not cause any irritation. Only frequently repeated 
large doses effected a disappearance of the parasites from the blood 
Very soon, however, trypanosomes reappeared again. The animal 
succumbed to a severe toxic haemorrhagic nephritis due to the 
Antimony. 
C. Rabbits. 
Six rabbits were inoculated with 7 '. brucei, and after the disease 
had become well established treatment was begun. But even 
prolonged administration of fairly large doses — OT gramme per 
injection was not able to cope with the disease, and all the animals 
succumbed to the infection. Although parasites were very rarely 
seen in the peripheral blood, the well-known symptoms of a Ngana 
infection were more or less pronounced during the wliole course of the 
treatment. 
D. Guinea-pigs. 
Treatment was only attempted in the case of three guinea-pigs, as 
rj ^ s^pparent that these animals did not bear well, effective 
doses of Antimony. It was found that if this drug was administered 
su cienty large doses to destroy the parasites, the animal died 
evere idney lesions; small doses, on the other hand, did not, 
even It administered repeatedly, have a noticeable effect on the 
parasites in the blood. 
It was noticed that on standing the ammo-phenyl-stibmic acid 
svmntn and caused on injection serious toxic 
into A ^ ^ decomposition of the compound 
into Aniline and Antimonic acid. 
