II. p. AMINO-PHENYL-STIBINIC ACID 
After the somewhat discouraging results obtained with the use of 
ni. Ammo-phenyl-stibinic acid, experiments were undertaken with a 
view to ascertaining whether the p. compound was superior in its 
action to the in. compound.* 
A. Rats. 
Rats infected with T. brucei, I . ei ansi, and T. gambitnst were 
used in the following experiments: _ 
The stiain of T. gambiense, with which the experiments were 
carried out, was an especially virulent strain. Tt was recovered from 
a monkey at the time of its last relapse, a few days before death. 
Rats succumbed to the infection, on an average, 3-4 days after 
inoculation. 
As a routine method of treatment, after some preliminary 
experiments, the following procedure was decided upon;-i5t day, 
injection of 0 5 c.c. of 5% solution, followed on the 3rd day by. 
5 o 5/4 solution. I'lie injections were repeated after a varying 
interval, as seen in Table III, pp. 
niode of treatinent was found to be superior to injections ot 
° ? r '"'ll subsequent days. Only a small 
which tooMheT"*** succumbed to the poisoning effects of Antimony, 
hich took the form of a severe d.arrhoea. At the post-mortem the 
nZed r rT ’""^'^^dly oedematous and 
The eVf ! ; - -ute inllammabcn. 
was very marked. compound on the trypanosomes 
hours If frp t parasites disappeared usuallv after 12-16 
com;ra:!v;“:;r:\:r ”■ ^ 
prompt disappearance Ore. • '"Jeution again caused their 
interval between relapses beran ^"'’ll injections the 
injection of the drugfed no in^ ^ shorter, until, finally, an 
animal died from t - - the parasites, and the 
these experiments. 'we‘‘”°er?rbirto 7 
-- -ere able to confirm Mesnil’s and Briraont’si- 
3 'senic acid 13 F-hrli^VriTat the w. Amiao-phenvl- 
--n.c acid (.Mo,v„. (Private 
