373 
observation that this strain is not resistant to the drug in the same 
sense as Atoxyl resistant strains. If subinoculated into new rats, an 
injection of the Antimony compound caused a prompt disappearance 
of these parasites from the blood. 
B. Dogs. 
Experiments with dogs infected with I . evansi and 1 . brucei 
showed that these animals are very susceptible indeed to the toxic 
effect of the p. Antimony compound. If small doses were 
administered, the parasites did not disappear from the blood. If the 
doses were increased, the animal died in a very short time with severe 
kidney lesions. At the post-mortem, the kidneys were swollen and 
congested ; subcapsular and cortical haemorrhages were noticed. Ihe 
urine was of a slight reddish colour, containing red blood corpuscles, 
casts, and large quantities of albumen. Table V, p. 377 « gives the 
details of these experiments. 
Preliminary experiments on guinea-pigs proved that these animals 
reacted to the p. compound in the same way as to the m. compound. 
C. Monkeys. 
Monkeys infected with I. ganibiense were used for the following 
experiments. Treatment was usually begun when the infection was 
'^’dl established, and the animals presented undoubted signs of illness. 
Two monkeys were treated at a late stage of the infection, two at an 
earlier stage with the p. compound. Two others were treated with a 
'Torabination of p. amino-phenyl-stibinic acid and Atoxyl. 
txPEWiiEST Xo. \\.—CcrcofHh<(us callitrichus, weight i k. 920 gm. ireat- 
Was begun seventy-two davs after infection. Numerous parasites were en 
fOQDd .- * .... .... - _ __ -h rnniDOund. 
uegun seveniy-tw’o uavs alter inietuuu. .> r — 
10 the blood. The animal was injected with 0-2 gm. of the ' 
^ parasites had disappeared hy the next morning. Symptoms o 
had, however, set in ; the monkey was vomiting ^^ite, slimy masses a 
assuffering from severe diarrhoea ; the eyes being congested. The 
noticed all over the body ; the eyes were glassy and string , _ 
™«D,brane of the mouth was cvanotic ; the temperature was . 
was dark and contained'numerous leucocytes. These symptoms increased, 
Ike animal died in the evening of the following day. • the 
I <he ixwt-mortein, numerous subpleurat haemorrhages were glowed 
H. .ere normal; ,he hear, pale and soft; the liver was very 
^■cal signs of a parenchymatous degeneration ; the spleen .;ubstance« 
pale and slightly congested ; the medullary 
well defined ; the mucous membrane of the stomach wa. g 
lh« • 
intesline.s oedematotts. 
