Expekiment XXVI.— Maeafus rhesus, weight ak. 245gm. Tteatineni was 
begun on the twentieth day after inoculation. The animal was then in a verv 
advanced stage of the disease. The face was puffy, the genitals swollen and 
oedematous. The blood count gave 1,570,000 red cells, 3,700 white cells and 
haemoglobin 55 per cent. o-i gm. of /. compound was then injected. The 
parasites disappeared about eleven hours after the injection, but the animal was 
found dead next morning in its cage. The post-mortem revealed the typical lesions 
of an advanced trypanosomiasi.s in monkeys. 
Two monkeys were inoculated at an earlier stage of the disease. 
Experiment XX. —Maeaeus rhesus, weight 2 k. 540 gm., was injected on the 
fifteenth day after inoculation with o-i gm. of f. compound ; a relapse set in nine 
days after the injection, when the same dose was repeated. Thirty-two days 
afterwards, a third injection of o-i gm. of the drug was administered, and then 
treatment was discontinued. The animal is still alive on the ninety-eighth day 
after inoculation, and has increased in weight to 2k. 72ogm. The period of 
observation is, however, far too short to consider this animal cured. 
Experiment XXIV. — Macacus rhesus, weight 1 k. 650 gm. Injected with 
T. gambiense. Very soon the animal showed oedema of the eyelids and oedematous 
swelling of the genitals. Treatment was begun thirteen days afterwards with an 
injection of o-i gm. of the f. compound. The parasites had disappeared from the 
peripheral circulation by the ne.xt day. The same dose was repeated on the 
twenty-first and thirty-.seventh day after inoculation*; the treatment was then 
discontinued. The animal is still alive, sixtv-four days after inoculation, and has 
increased in weight to i k. 720 gm. 
In order to ascertain the value of a combined Antimony-Atoxyl 
treatment in monkeys infected with T. gambiense, two monkeys 
(^Macacus rhesus') were used in the following experiments: — 
Experiment XXII. —Macacus rhesus, weight 2 k. 190 gm. The animal was 
injected twenty-Three days after inoculation with o-i gm. of compound. The 
parasites disappeared promptly from the peripheral circulation. This was followed 
on the thirty-first day by an injection of o-i gm. of Atoxyl. On the forty-eighth day 
the injection of o-i gm. of the f. compound was repeated. The animal is still 
alive, sixty-two days after inoculation, and ha.s regained its original weight. 
Experiment XXV. — Macacus rhesus, weight i k. 985gm. It was treated in the 
same way as in Experiment XXII. This animal is still alive, but in both cases 
the observation time is far too short to pronounce the animals cured. 
u oiuiv a 
1. The foregoing experiments prove that p. and in. amino-phenyl- 
stibmic acids are fairly powerful trypanocides. although their action is 
not so rapid as that of Sodium-antimonyl-tartrate. 
2. That the p. amino-phenyl-stibinic acid is decidedly superior 
in Its artion to the m. amino-phenyl-stibinic acid. 
3. Considering the satisfactory results obtained in experimental 
anima s, a trial of the p, amino-phenyl-stibinic acid in patients 
suffering from Sleeping Sickness is justifiable. 
^ Opinion p. amino-phenyl-stibinic acid may be 
same doses as Atoxyl. As kidney lesions are 
sviifF-TM f *^ost pronounced results of Antimony poisoning a careful 
systematic exam.nat.on of the urine is advisable 
