6l2 EXPERIMENTS WITH CARBOLIC ACID. 
seen in the brain substance; each lateral ventricle contained 
a small quantity of serous fluid. 
6th December.—Dog,No. 5,at 8.30 a.m., was thin and froth¬ 
ing at the mouth, nevertheless 5ss of acid in 3iv of water was 
given, and immediately after gr. iv of Calabar bean powder 
which had been steeped for ten minutes in 3ij of spirit of wine, 
was also given ; he fell and was strongly convulsed. In two 
minutes he was put in warm bath and was kept in for one 
minute without any apparent benefit. He died in ten minutes 
from the time of taking the acid. 
Post-mortem at twelve o’clock midday.—All internal organs 
gorged w T ith blood as in No 4; there was also serous effusion 
on the surface and in the ventricles of the brain. The spine 
from the shoulders to the sacrum was laid open, but no 
effusion or signs of inflammation could he detected in the 
cord or its sheath. 
7th, at 8.10 a.m.—5ss acid in ^iv of water was given to dog 
No. 6. In thirty seconds he was staggering about. In two 
minutes he was put into hot bath and kept in for two 
minutes, then taken out and wrapped in a blanket; this 
served to check the spasms, but not the heavy breathing. At 
8.20 he got up, and the effects of the dose had quite worn off 
by 8.30 a.m. 
Thinking that, perhaps, the Calabar bean had something to 
do with killing dogs No. 4 and 5, I caught another dog on 
the 7th December and gave him gr. ij of powdered bean in a 
3iss of spirit, vini, with 5ij of water. In three minutes he 
coughed a little, and then vomited; the cough continued at 
intervals for about twenty minutes, but no other effects were 
noticeable. On the next morning (8th December), however, 
a weakness in his hind quarters was quite evident, as seen 
by the way he walked. 
At 8.48 a.m. gr. ij of Calabar bean powder in cold water 
was given; he vomited immediately, but no further effect fol¬ 
lowed, nor was the weakness in his gait more evident the 
next day. From this I attribute the death of dogs 4 and 5 
solely to the carbolic acidd 
On the 13th of December, “ Culloo,” a prisoner, Hindoo, 
aged 22, was admitted into hospital, complaining of purging; 
stools semi-fseculent, frothy, with mucus in them ; tenderness 
of descending colon ; straining at stools ; no fever. Gave dose 
of 01. and the next day gallic acid with opium three times. 
No improvement on morning of 15th. I then gave carbolic 
acidiqiij, c. tinct. opii Hxv, in jss camphor water. On 17th 
his stools were natural; the medicine omitted. He was dis¬ 
charged cured on the 18th. 
