844 GASTRIC JUICE AND PEPSIN APPLIED TO WOUNDS. 
Meadow-hay was then exhausted consecutively with water, 
alcohol, and three per cent, soda-ley. The alcoholic extract 
produced a slight increase in hippuric acid; the watery and 
alkaline extracts and the residue had no appreciable effect. 
The non-formation of hippuric acid from this residue is in 
opposition to the observations of Meissner, who from experi¬ 
ments on rabbits arrived at the conclusion that the formation 
of this acid was due to the digestion of some substance con¬ 
tained in the crude fibre, probably the cuticular membrane. 
That the nitrogenous constituents of the food do not wholly 
regulate the secretion of the acid is proved by the facts that 
the addition of rape cake to the food had no action on its 
quantity, but only increases the urea, and that a much 
smaller quantity is formed by feeding with clover than with 
graminaceous plants. 
Neither do the aromatic substances of the food seem to 
have much influence: for the^ alcoholic extract of meadow- 
hay, containing the greater part of the aromatic bodies, pro¬ 
duced but a small quantity of hippuric acid, and Henneberg 
and Stohman found as much in the urine of oxen when fed 
on oat-straw as when eating meadow-hay. 
By gradually increasing the quantity of oat-straw given in 
combination with clover-hay, the hippuric acid secretion in 
the urine of sheep was gradually increased; in a similar 
experiment with barley-straw no such increase took place. 
Notwithstanding contradictory appearances, the author 
still thinks that the secretion of hippuric acid is influenced 
by the protein matters and the fibre of the food, though the 
conditions necessary can only be found by a closer examina¬ 
tion of these substances.— Versuchs-Stationen Organ. 
GASTRIC JUICE AND PEPSIN APPLIED TO WOUNDS. 
The New York Medical Journal states that there have been 
performed recently a number of experiments with the above 
fluids, applied as follows:—The gastric juice of dogs was 
pencilled, at short intervals daily, fifteen to twenty minutes 
upon the wounded surface, or small pledgets of cotton were 
applied, and upon them a second larger layer of wadding 
dipped in a very dilute solution of muriatic acid. Several 
experiments were made, especially upon chancres, upon soft 
chancres in particular. After five to eleven days, commencing 
cicatrization followed as a rule. The remedy is chiefly indi- 
