HERMANN M. BIGGS. 
818 
cauterized twelve hours after the accident, so that, in the opinio 
of Dr. Yulpian and Dr. Grancher, the boy seemed certainly de 
tined to develop hydrophobia. He was accordingly subjected I 
the following inoculations: 
July 6th, 8 p.m., spinal marrow of June 21st, 15 days old. 
it 
7 th, 
9 A.M., 
ft 
tf 
ft 
23d, 
14 
tf 
if 
it 
7th, 
6 P.M., 
ft 
ft 
ft 
25th, 
12 
tf 
ft 
it 
8 th, 
9 A.M., 
ft 
ft 
if 
27th, 11 
ft 
tt 
it 
8 th, 
6 P.M., 
ft 
ft 
«t 
29th, 
9 
ft 
ft 
it 
9 th, 
11 A.M., 
ft 
ft 
July 
1st, 
8 
tf 
ft 
tt 
10th, 
11 A.M., 
tf 
tf 
ft 
3d, 
7 
ft 
tt 
a 
11th, 
11 A.M., 
ft 
ft 
ft 
5 th, 
6 
ft 
ft 
tt 
12tli, 
1 P.M., 
ft 
ft 
ft 
7th, 
5 
ft 
tt 
tt 
13th, 
11 A.M., 
tt 
ft 
ft 
9 th, 
4 
ft 
ft 
tt 
14th, 
11 A.M., 
tf 
ft 
ft 
11th, 
3 
ft 
tf 
ft 
15th, 
11 A.M., 
ft 
ft 
tt 
13th, 
2 
tf 
ft 
tt 
16th, 11 A.M., 
ft 
ft 
ft 
15th, 
1 day 
ft 
Pasteur says of this case: “ I dare say that a smaller numbt 
of inoculations would have been sufficient,'but it is easy to unde 
stand that the first trial was made with the observation of ever 
possible precaution.” 
In order to determine the virulence of the virus used, tv 
rabbits were inoculated each day in the usual manner with th 
same virus as that used for the boy. These inoculations showe 
that the cords used on the 6th, 7th, 8th, 9th and 10th of Ju 
were not virulent, since they did not produce rabies in the rabbi 
inoculated on these days. The cords used on July 11th, 12t! 
14th, 15th and 16th were all virulent, and were of a constant 
increasing virulence. Habies appeared after seven days of inc 
bation in the rabbits inoculated with the cords of July 15th ai 
16th, after eight days in those of the 12th and 14th, and aft* 
fifteen days in those of July 11th. Notwithstanding the fact tha 
in the last inoculations, virus was used which was far more virulei 
than that of rabid dogs, still these inoculations were followed l 
no symptoms, and now that more than six months have elapse 
since this boy was bitten, he yet remains perfectly well. 
The methods used for the preservation of the spinal cords ar 
