PATHOLOGICAL PHYSIOLOGY. 
513 
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[NFLUENCE OF THE ORGANISM OF GUINEA-PIG UPON THE VIR. 
ULENCY OF TUBERCULOSIS AND SCROFULA. 
By M. S. Arloing. 
We have demonstrated that pulmonary tuberculosis affects 
guinea-pigs and rabbits, while true gangliomar scrofula produces 
tio lesion in the last named animal. From this fact we did not 
iare conclude that both processes were specifically different, but 
WCIG obliged to admit that if they derived from one agent, its 
ictivity seemed considerably attenuated in scrofula. Starting 
rom this, it was interesting to find out if the virulency of scrof • 
ila could be sufficiently increased to render it able to infect either 
me of those animals. 
The organism of guinea-pig is extremely favorable to both 
uberculosis and scrofula. This last develops itself so easily and 
assumes such degree of malignity, that it is justifiable to believe 
hat if it was made to last several generations upon this animal, 
t would be capable of destroying the resistance presented to it 
)y the rabbit’s organization. 
Experiments made in that direction have shown that the pas- 
age of scrofula on the guinea-pig, during two successive genera- 
ions, does not increase its virulency for the rabbit, and does not 
nodify to any sensible extent that which it possesses for the 
obays. 
The result is different with true tuberculosis under its attenu- 
ted forms. 
Among the bony and articular diseases of men known as 
| or surgical tuberculosis, some are beyond, while others are 
onsiderably improved if not cured, by surgical interference, 
’hose are manifestations of scrofula, others are tubercular, of a 
)ss virulent nature than tuberculosis of the lungs or serous mem- 
ranes. If, then, simultaneously, inoculations are made on rab- 
its or guinea-pigs with the lesions of this nature, the pigs may 
resent the classical lesions of the most generalized tuberculosis, 
File the rabbits will escape with a small purulent collection or 
| nail granulations of the subcutaneous cellular tissue at the point 
f inoculation, as if it followed a simple scrofulous inoculation, 
lit again, inoculate rabbits with the tubercules thus developed 
