436 ANALYSIS OF CONTINENTAL JOURNALS. 
are larger and more painful. It seems, however, that the 
inoculations with the needle have a considerably less develop¬ 
ment at the outset than those made with the lancet. Expe¬ 
rience has taught that there is no harm in the flow of a small 
quantity of blood; this incident occurs almost always in 
every case of inoculation, but is in no way detrimental to 
the success of it. The majority of the heifers were in good 
condition when they were given up by the butchers for the 
experiments, and nearly all remained in a state of perfect 
health. Some of them (four) were affected with diarrhoea 
when they entered the establishment; three others were 
attacked with the same complaint after the inoculation had 
commenced ; two amongst the rest became very emaciated 
and weak, but none died. We do not count the one bought 
at Orleans, which had been some considerable time in the 
institution, and died under peculiar circumstances, which w^e 
shall describe hereafter. It must be admitted that the health 
of the animals has great influence over the development of 
the pustules. The heifers which had become weak and 
exhausted by the diarrhoea showed a less full pustule than 
those which fed well and were in perfect health. The same 
holds good when the vaccine is transmitted from child to 
child. 
The pustules have never pointed before the end of the 
second day, but generally before the fourth. It almost always 
occurs about the end of the third day that the first indica¬ 
tions are perceived. They increase in size to the end of 
the sixth day, and in general they attain their full develop¬ 
ment from the seventh to the eighth day, aftei»which they 
rapidly become purulent and take on a marked yellowish tint. 
Desiccation sets in and the scabs become more and more 
brown, and begin to come off from the fifteenth to the 
twentieth day, leaving at first a depressed cicatrix of a red¬ 
dish, and afterwards white, colour. As to the general phe¬ 
nomena, they were nil in the majority of the cases. In five 
or six of the animals a slight prostration and heat of the 
skin were noticed, partly in those that had been suffering from 
diarrhoea. It was also ascertained by these experiments, and 
the fact was carefully noticed, that the eruption only appeared 
at the punctures of the inoculation, and never spread beyond 
them, but we could not venture to affirm that this would be 
always the case; at the same time w’e considered it impor¬ 
tant and W’orthy of being recorded. The inoculations were 
made with the virus of two different origins, viz. that from 
Naples and that of the heifer of Beaugency, but the results 
were identically the same, either in the progress, form, or 
