ANALYSIS OF CONTINENTAL JOURNALS. 
437 
size of the pustules. Right or wrong, many medical prac¬ 
titioners complain of the deterioration of the lymph, which 
they attribute to the successive transmission from child to 
child, and believe that the proof of it lies in the smallness 
of the size of the pustules. The commission, without pro¬ 
nouncing on this delicate question, had to find out whether 
the successive inoculation of the same vaccine, used on a 
great number of animals, had the effect of progressively 
decreasing the size of the pustules. The commission made, 
to ascertain the fact, forty-two experiments with the 
vaccine of Beaugency, and came to the conclusion that 
nothing of the kind resulted from it; on the contrary, the 
drawings of the pustules made from the last experiment 
showed them to be as fully developed as those of the first. The 
time we were enabled to keep the heifers, after a first inocual- 
tion, only allowed us, in one instance, to ascertain whether they 
were apt to take it a second time in case of reinoculation ; this 
was tried in the one bought at Orleans. The experiment was 
made on the 5th of June, thirty-five days after the first inocu¬ 
lation ; she was reinoculated with the virus taken from 
No. 6, eight punctures being made on the inferior parts of 
the abdomen with a vaccinating lancet, the case being care¬ 
fully watched; the result was a complete negative of a 
successful reinoculation. 
This report goes further to show that at a small cost 
animal vaccination might be kept up so as to supply vaccine 
to all the great centres of population. The vaccinations at 
the Academy take place twice a week, viz. Tuesday and 
Saturday, and it was important to vaccinate concurrently with 
the animal lymph and with that obtained from arm to arm; 
the director of the vaccine establishment alternated these 
two modes of vaccination as much as the circumstances per¬ 
mitted, the former being employed about once a week, the 
details of which will form the subject of a future part of this 
report, which will show that the number with the cow-pox 
was very considerable, and that if that from arm to arm was 
exceeded it is explained by the fact that on certain days the 
number of children was greater, a circumstance over which 
there was no control. 
As to the quantity of vaccine collected on glass plates and 
in tubes, it was very considerable and more than the vaccina¬ 
tion service required. From the 15th of April to the end of 
December the commission forwarded to the different vaccinat¬ 
ing establishments 2093 glass plates and 1757 tubes charged 
with vaccine from the heifers experimented on, to which must 
be added that which was given to members of the profession for 
