VACCINATION OF SHEEP. 
843 
REPORT OE EXPERIMENTS MADE UNDER DIRECTION OE 
THE LORDS OE THE COUNCIL AS TO THE VACCINATION 
OE SHEEP, AND AS TO THE INELUENCE OE SUCH VAC¬ 
CINATION IN PREVENTING SHEEP-POX. 
By James F. Marson, Esq., F.R.C.S., Resident Surgeon 
of the Smallpox Hospital, and 
Professor Simonds, of the Royal Veterinary College. 
(Continuedfrom p. 633.) 
The vaccine disease in the sheep, even when developed to 
its fullest extent, is very unlike the same disease in the 
human subject. In the sheep it is but seldom anything 
more than the production of a small papule, which occasion¬ 
ally results in the formation of a minute vesicle, or more 
commonly a pustule, which is sometimes, although very 
rarely, surrounded with a slight areola. Generally, how¬ 
ever, neither vesication nor pustulation follows, but a small 
scab is produced, which soon falls from the site of the punc¬ 
ture, leaving no trace behind. The disease passes quickly 
and irregularly through its several stages, so as to have 
ended by the eighth or ninth day, or not unfrequently even 
before this time. Lymph is but rarely obtainable, and never 
but in the smallest quantity, and this on the fifth or sixth 
day succeeding the vaccination. The effects are only local, 
and the animal’s health never impaired. In man, on the 
contrary, vaccination can nearly always be made to take 
effect, a vesicle being formed on the eighth day, affording 
regularly lymph for the vaccination of others, which is 
always, or nearly always, followed by areola, the vesicles 
being never so small as those observed in sheep, excepting 
in what are called abortive or spurious cases, which, however, 
in well-conducted vaccinations, are of very rare occurrence. 
Our observations, therefore, fully confirm the remarks of 
Mr. Ceely, of Aylesbury, who says, “That imperfect deve¬ 
lopment and premature decline, with little or no areola, is 
the rule” in the vaccination of sheep. 
Besides the 200 ewes, two rams were vaccinated. In one 
ram, effects rather greater than those usually observed were 
produced in four of the punctures, and in two of them in the 
other ram. Both these animals were subsequently ovinated 
and contracted the sheep-pox, passing regularly through its 
several stages. Both recovered. Six lambs were also se¬ 
lected for vaccination, four of which were operated on with 
Smallpox Hospital lymph, and two with primary lymph. 
The Smallpox Hospital lymph took effect in all four 
