INFECTIVE AND CONTAGIOUS DISEASES. 
25 
ganisms sometimes pass directly through the lymphatic walls, so 
swelling of the glands in the vicinity of the inoculated part first 
occurs. In the higher ruminants and horses, swelling occurs at 
the seat of inoculation, and the poison multiplies in the serum 
of the parts, it is then absorbed into the lymphatic glands of the 
part where it continues to multiply, and it thus causes swelling; 
it is more likely that it pierces the walls of the smaller blood¬ 
vessels, and thus gains the round of the circulation, than that it 
passes by way of the thoracic duct. Thus in some cases the 
glands do not seem to be affected, but the Bacilli mainly occur 
in the capillaries. In the mouse, guinea pig, and other small 
mammals, the symptoms after inoculation may be practically nil, 
the temperature rising two or three degrees, and falling again 
before death to as much below the normal; in the latter stages 
a cyanotic condition has been observed. At first only a few 
Bacteria can be observed on a slide in a drop of blood, but later 
they are more numerous. Often, however, Bacteria cannot be 
seen in the blood, the white corpuscles are increased in number, 
and the spleen is not generally enlarged in the guinea pig. The 
Bacilli are found to be more irritant than when taken directly 
from a diseased animal than after cultivation. 
The blood of the animals subject to experiment is interesting 
as having its white corpuscles increased in number, containing 
many Bacilli, and in that coagulation does not freely occur. 
Sometimes the filaments are longer than three or four red corpus¬ 
cles. The suppurative infective properties of anthrax-virus 
disappear on putrefaction but perhaps not entirely. To test this 
the lecturer allowed a guinea pig which died from anthrax, to 
remain after death exposed to putrefactive influences; after nine 
days Bacilli remained. On the sixteenth day the body swarmed 
with spores, remains of filaments, and spores with portions of 
filaments attached. A small amount of fluid containing these 
communicated the disease to a guinea pig. Mode of action of 
the Bacilli; it is known that they depend on the presence of 
free oxygen for free growth, and therefore, they have been 
supposed to deprive the red corpuscles of oxygen. This is not 
yet proved, for there can be no doubt that the obstruction to 
the passage of blood through the lungs prevents it from obtain¬ 
ing its obtaining its proper amount of oxygen, which would 
aecount for the small amount of oxygen in anthrax blood. The 
irritant action of the organisms must also be remembered. But 
the morhid anatomy throws some light on this matter, an enor¬ 
mous number of Bacilli are found, but they do not seem to be 
especially abundant in the spleen. In the heart they abound 
within and around the vessels, and in the interspaces of the 
muscular fibres. After they so crowd the small vessels as to 
