LANCASHIRE VETERINARY MEDICAL ASSOCIATION. 3f)3 
The best illustrations of proliferation of tissue corpuscles can obvi¬ 
ously be obtained by studying the process of inflammation in the least 
vascular tissues, such as cartilage and cornea. Redfern, in the Edinburgh 
Medical Journal , 1849, described in minute detail the changes observed 
in ulceration of articular cartilage. He recognised that after the 
introduction of a seton, the first departure from health consisted in an 
enlargement of the cartilage cells, which became five or six times their 
natural size, at the same time they became irregular in their distribu¬ 
tion in the cartilage. The diagram, No. 6, representing the changes 
seen in inflamed cartilage, is copied from one by Corned and Ranvier. 
The normal cartilage cells are represented at the left hand corner, and 
a little to the right the cells enlarged with many nuclei ; still further 
you see the cells multiplied within their capsules; at the extreme right 
hand a mass of young cells are illustrated, now occupying the extent of 
the original corpuscles and matrix. The matrix, represented with a 
bluish tint in the diagram, gradually breaks down and disappears. 
Redfern thought that the young cells thus produced did not become 
pus cells, but Weber subsequently showed that pus cells may thus be 
generated. The series of changes I have briefly sketched, constitutes 
an important step in the doctrine of parenchymatous inflammation. 
Similar phenomena have been recorded in inflammation of the non- 
vascular cornea by Strube and His, also by Virchow. 
Acute catarrhal inflammation, or inflammation of a mucous membrane, 
has afforded examples of suppuration on epithelial surfaces. This 
diagram, No. 7, after Rindfleisch, is intended to represent the appear¬ 
ances presented by inflamed conjunctiva on a vertical section. You 
recognise the epithelial elements tinted yellow, and underneath these 
the submucous connective tissue. The generation of pus from the 
actual elements may have a double source. If the pus cells on the 
free surface of the epithelium in the diagram are produced by prolifera¬ 
tion of the epithelial cells themselves, it is evident that pus may be 
formed without abrasion of the surface. If, however, the pus cells owe 
their origin to multiplication of the deeper connective-tissue corpuscles 
ulceration of the superjacent epithelium must ensue. It is now main¬ 
tained that pus cells take origin by proliferation of the deeper epithelial 
cells. In the same diagram some large so-called mother-cells are dis¬ 
played with their contained broods which are expelled as pus corpuscles. 
It has been suggested by Volkmann that these mother-cells have simply 
derived their contents from the young cells of the underlying connective 
tissue. The mother-cells, therefore, are capable of a double interpretation, 
that is to say, the young cells are taken up by an epithelial cell from 
without, or produced by endogenous multiplication in the epithelial cell 
itself. 
The origin of pus in glandular abscess has been ascribed to multiplica¬ 
tion of the proper glandular cells, and to the connective-tissue corpuscles 
having a similar double source, on which I need not dilate. 
Having brought before you some points in connection with the forma¬ 
tion of pus in abscess, and on mucous surfaces, I will now allude to the 
connection of pus with granulation tissue, as seen in wounds. Before 
commencing this portion of my subject, let me shortly describe the 
structure of granulation tissue. 
Inflammatory new formation, or ordinary cellular tissue, as observed in 
the healing of wounds, was designated by Virchow “granulation tissue, 5 ’ 
and by Rindfleisch “ germ tissue.” It consists of a greater or less number 
of cells agreeing with the leucocytes of the blood or the wandering cells 
of connective tissue. By a reference to the diagrams 4 and 5, you notice 
