Jan. 20 , 1923 
Carbon Tetrachlorid as an Anthelmintic 
167 
No. 17; 5 cc.; passed no worms; postmortem, 10 worms; efficacy, o 
per cent. 
No. 18; 3 cc.; passed 24 worms; post mortem, 70 worms; efficacy, 35.5 
per cent. 
No. 19; 2 cc.; passed 41 worms; post mortem, no worms; efficacy, 100 
per cent. 
Total worms passed, 147; total remaining post mortem, 80; efficacy, 65 
per cent. 
All the worms were removed from 4, or 66.6 per cent, of the 6 birds 
listed above. While the smallest dose, 2 cc., was as effective as the 
largest dose, the removal of all the worms present seems more certain 
where the larger doses are used. The most satisfactory treatment for the 
removal of these worms was found to be the rectal injection of 0.1 cc. of 
oil of chenopodium in 5 cc. of a bland oil (cottonseed oil). The dose for 
birds weighing 3 pounds or more would be double this, or 0.2 cc. in 10 cc. 
of bland oil. The injections were made with an infant’s-size rectal 
syringe of hard rubber, the tip of the syringe being passed along the floor 
of the cloaca and the fluid injected slowly. 
TESTS ON RABBITS 
The following tests of the toxicity of carbon tetrachlorid administered 
by stomach tube to rabbits were conducted: 
Rabbit No. 7213.—Weight 2.055 kilos; dose 5 cc. per kilo; animal off 
feed for a few days, but no other ill effects noted; discharged from experi¬ 
ment eight weeks later. 
Rabbit No. 7214.—Weight 1.755 kilos; dose 10 cc. per kilo; animal 
stupid the following day, dull and weak the second day, found dead the 
morning of the third day; post mortem, stomach inflamed and slightly 
hemorrhagic in cardia, small and large intestines showed areas of sub¬ 
mucous hemorrhages and some hemorrhage to lumen, liver pale, heart 
muscle injected, anterior lobes of lungs congested and some marginal 
edema present, peritoneal fluid excessive and slightly sanguineous, blad¬ 
der apparently normal. 
Rabbit No. 7215.—Weight 1.97 kilos; dose 15 cc. per kilo; animal 
died the following day; post mortem, stomach inflamed showing 
hemorrhagic areas, small intestine with areas of inflammation and 
ecchymoses, large intestine congested, carbon tetrachlorid recovered 
from stomach and large and small intestines, heart vessels congested, 
lungs showed more or less extensive capillary hemorrhage, vessels of 
urinary bladder congested. 
Rabbit No. 7216.—Weight 1.65 kilos; dose 20 cc. per kilo; animal 
died the following day; post mortem, evidence of diarrhea, gastric cardia 
showed hemorrhagic eroded areas, ecchymoses in small intestine, large 
intestine congested, carbon tetrachlorid recovered from stomach and 
large and small intestines, heart vessels congested, urinary bladder empty 
and its blood vessels injected. 
These tests indicate that rabbits will tolerate doses of carbon tet¬ 
rachlorid at the rate of 5 cc. per kilo, but will die in the course of 2 days 
after a dose at the rate of 10 cc. per kilo and within 24 hours after a dose 
at the rate of 15 or 20 cc. per kilo. The minimum lethal dose rate is 
therefore between 5 and 10 cc. per kilo, apparently close to 10 cc. per 
kilo. The experiment indicates that carbon tetrachlorid passes through 
the digestive tract unabsorbed in most part, but that in large doses 
