172 
Journal of Agricultural Research voi. xxm, no. 3 
2 ascarids. The subsequent history was the same as that for No. 5, but 
the symptoms were less severe following a larger dose (to be reported 
below). 
Cat No. 7.—Six-weeks-old kitten, weighing 960 gm.* Given 4.8 cc. of 
carbon tetrachlorid by stomach tube, a dose rate of 5 cc. per kilo. Within 
an hour the cat vomited 3 ascarids and during the night it passed 14 as¬ 
carids. The subsequent history was the same as for No. 5 and 6, 
but the symptoms were more severe following a larger dose (to be re¬ 
ported below). 
Two weeks after these animals (No. 5, 6, and 7) had been given the 
foregoing treatments, they, now 2 months old, were given larger doses 
of carbon tetrachlorid as follows: 
Cat No. 5.—Weight 620 gm. Given 3.72 cc. of carbon tetrachlorid by 
stomach tube, a dose rate of 6 cc. per kilo. The animal vomited within a 
half hour after treatment but did not seem greatly affected. It drank 
milk 3 or 4 hours after treatment and seemed quite normal the following 
day. 
Cat No. 6.—Weight 740 gm. Given 5.18 cc. of carbon tetrachlorid by 
stomach tube, a dose rate of 7 cc. per kilo. The animal did not vomit 
after treatment and did not seem greatly affected by it. It drank milk 
3 or 4 hours after treatment and seemed quite normal the following day. 
Cat No. 7.—Weight 940 gm. Given 7.52 cc. of carbon tetrachlorid 
by stomach tube, a dose rate of 8 cc. per kilo. This animal showed pro¬ 
fuse salivation after treatment and pronounced evidence of intoxication. 
There was evident improvement in its condition in the course of 3 or 4 
hours, and it seemed quite normal the following day. 
So far as conclusions can be safely drawn from these experiments, it is 
evident that carbon tetrachlorid has a wide margin of safety between 
the therapeutic dose of 0.3 cc. per kilo and the minimum lethal dose. 
Cats No. 3 and 4 were not in very good physical condition, and it is possi¬ 
ble that stronger animals would have survived the doses which killed 
these animals. At any rate, the survival of animals given 8 cc. per kilo 
gives an indicated safety factor of almost 27, which is considered high. 
It indicates that members of the Felidae, as well as of the Canidae, 
are highly tolerant of carbon tetrachlorid. 
In connection with the effects of carbon tetrachlorid taken in milk by 
one of the writers and discussed later in this paper, the drug was given as 
follows to cats No. 6 and 7 five days after they were given the second dose 
as reported in the preceding tests: 
Cat No. 6.—Given 3.7 cc., a dose rate of 5 cc. per kilo, in 5 cc. of rich 
milk. The animal did not vomit, and showed no ill effects. 
Cat No. 7.—Given 3.7 cc., a dose rate of almost 4 cc. per kilo, in 5 cc. 
of olive oil. The animal did not vomit, and showed no ill effects. 
The use of milk and oil did not result in an evident increase of toxicity. 
The same day on which these cats were treated the third time, cat No. 
5 was killed and examined post mortem. There were no worms 
present. The liver was light-colored. 
TEST ON FOXES 
The writers have carried on no experiments with carbon tetrachlorid 
for removing worms from foxes, but a number of reports of such experi¬ 
ments, in conversation and in correspondence as well as in published 
papers, have come to their attention. So far these reports have been 
