Jan. 20,1923 
Carbon Tetrachlorid as an Anthelmintic 
175 
1 dead, partly digested ascarid in the stomach and 7 live ascarids in the 
small intestine post mortem; pig 3382 passed 34 ascarids and had none 
post mortem; pig 3383 passed 9 ascarids and had 10 live ones post 
mortem; pig 3384 passed 2 ascarids and had 4 post mortem. The treat¬ 
ments were, respectively, 75, 100,47, and33 per cent effective. There were 
63 ascarids removed (including the worm killed but not yet passed) and 
21 left, an efficacy for the series of 75 per cent. The dose rate here is 
from 0.55 to 0.7 cc. per kilo, the efficacy rising from 33 per cent to 100 
per cent with the increasing dose rate. These animals were apparently 
not properly fasted. 
A second series of 5 pigs was treated as follows: Pig 3385, weighing 
23 pounds, was given 12 cc. of the drug in 12 cc. of castor oil and died 
within 48 hours without passing any feces; post mortem it had 5 whip¬ 
worms and 3 nodular worms; the digestive tract showed areas of high- 
grade inflammation. Pig 3386 was held as a control animal without 
treatment; post mortem it showed 17 ascarids, 14 whipworms, and 
1 lungworm. Pig 3387, weighing 26 pounds, was given 6 cc. of carbon 
tetrachlorid in hard capsules; it passed 2 ascarids; post mortem it 
had 13 whipworms; this animal had an abscess involving the upper 
esophagus and posterior larynx, probably due to the administration of 
the capsules by the balling gun. Pig 3388, weighing 21.5 pounds, was 
given 6 cc. of carbon tetrachlorid in one large capsule, the animal dying a 
few minutes later, apparently as the result of the entrance of the capsule 
into the trachea. 
A summary of the findings in this series shows that in the case of 2 
animals weighing 9 to 10 kilos, each of which was given 6 cc. of carbon 
tetrachlorid in capsules in one case and in 25 cc. of castor oil in the 
other, all the ascarids were removed. The animals had been fasted 
from noon of the previous day, and under these conditions the dose 
rate of 0.6 to 0.67 cc. per kilo was entirely effective in removing ascarids. 
The use of a balling gun to administer capsules produced an abscess 
in the case of one of these animals, and in the case of another animal, 
where a large capsule was used, it caused death by forcing the capsule 
into the trachea. A dose of 12 cc. of carbon tetrachlorid in an equal 
quantity of castor oil, or about double the dose rate of 0.6 cc. per kilo, 
caused the death of one of the animals treated. If this dose had been 
administered in a larger quantity of castor oil so as to diminish the irrita¬ 
tion and lessen the amount of inhalation of carbon tetrachlorid, it might 
have been tolerated. The results of this series of tests suggest that 
the drug may be satisfactorily administered to swine, from the stand¬ 
point of safety, in castor oil after an adequate fast (24 hours at least, 
and possibly 36 hours would be better), and that when so administered 
it will in many cases remove all ascarids present when given at the rate 
of 0.6 cc. per kilo. 
A series of tests on a large animal were made as follows: Pig 3384, 
weighing 125 pounds (about 57 kilos), was given 8 cc. of carbon tetra¬ 
chlorid in 60 cc. of castor oil; no worms were passed during the next 
4 days; it was then given 16 cc. of carbon tetrachlorid in 60 cc. of castor 
oil; no worms were passed during the next 5 days; it was then given 
32 cc. of carbon tetrachlorid in 60 cc. of castor oil; the next day the 
animal passed 1 ascarid, no other worms passing during the next 4 days; 
it was then given 40 cc. of carbon tetrachlorid in 60 cc. of castor oil; 
no worms were passed during the next 5 days; it was then given 32 cc. 
