i86 
Journal of Agricultural Research 
Vol. XXIII, No. 3 
worms and 32 whipworms. The spleen, liver, and kidneys were appar¬ 
ently normal. All the patients were negative for hookworms on fecal 
examination 3 weeks after treatment. The drug was given without 
purgation and had a marked cathartic action, the bowels moving in most 
cases in 3 to 5 hours after treatment. Urine examinations were made 
in two cases before and after treatment and showed no alterations as a 
result of the treatment. The pulse and the diastolic and systolic blood 
pressure were noted before and after treatment and showed that the heart 
action was practically undisturbed. The patients experienced only 
slight giddiness and a sensation of weight in the stomach for the most 
part. One patient had diplopia and nausea. The patient receiving 10 
cc. complained of giddiness, nausea, and drowsiness, but after sleeping 4 
hours the nausea disappeared and the giddiness diminished. 
Owing to a lack of capsules, the drug was given in 20 cc. of water, 
which might account, in our opinion, for some symptoms as a result of 
inhalation. The ineffectiveness of the drug against pin worms and whip¬ 
worms might also be correlated to some extent with the fact that the 
patients were allowed food immediately after treatment. In our opinion 
this might lower the efficacy of the drug. 
Nicholls and Hampton ( 28 ) have given a further report on the tests of 
the drug in Ceylon. They report its administration to 20 students, 18 
to 25 years old, in an agricultural school, 3 cc. being given without sub¬ 
sequent purgation. They state that the students carried out the regular 
program of the day without restrictions and that— 
Not one of them was inconvenienced by the drug, and they all continued their 
day's work in the gardens or at the school house. 
Microscopic examination of the feces 10 days later showed hookworm 
eggs in the feces of only 2 students, and the group passed an average of 
36 hookworms each, together with a total of 13 ascarids. The drug was 
then given to 64 students from 7 to .17 years old, in quantities of 1 to 3 
cc., food being allowed an hour later. These writers say: 
One 12-year-old. boy vomited when he had finished his meal, but the manager 
informed us that this child often vomited. . . . The drug acted as a mild 
aperient. The patients passed an average of 43.3 hookworms and a total of 260 asca¬ 
rids, 15 whipworms, and 4,945 pinworms. . . . The discharge of Trichuris and 
Oxyuris indicates that the drug acts throughout the intestinal tract, for we have not 
previously seen Trichuris expelled after the use of other anthelmintic drugs, or Oxy¬ 
uris vermicularis expelled in such large numbers. 
Ten days after treatment fecal examinations of 54 of these students 
showed hookworm eggs in 6 cases. 
The drug was given to four children 3 to 6 years old, previously treated 
once or oftener with chenopodium, removing 9, 35, 52, and 52 hook¬ 
worms. It was given to five children 4 to 9 years old, of whom one had 
malaria, one an enteric disorder, and three a pyrexia of unknown origin 
continuous in two cases and irregular in one case. These children passed 
from 6 to 167 hookworms each and were in no way inconvenienced by 
the treatment. 
These writers state : 
The drug may be administered safely in doses of 10 to 20 minims to children of 3 
and 4 years of age, even when they are seriously ill from various cases. It aids the 
expulsion of A scans lumbricoides if it is followed by a purgative, but it is not as effec¬ 
tive as chenopodium in killing this worm. The drug does not seriously deteriorate 
on keeping. Many children were given doses of carbon tetrachloride which had been 
stored in the laboratory for 3 years. It is more valuable than chenopodium for cam¬ 
paigns against hookworm disease because (a) patients do not object to its taste; (b) it 
is not necessary to precede or follow the administration of it by a purge; (c) it is much 
