190 
Journal of Agricultural Research 
Vol. XXIII, No. 3 
Other symptoms which are sometimes manifested are tinglingor burning 
sensations and drowsiness. Rarely, usually following the administration 
of rather high doses, the drug may cause nausea, vomition, irregularity 
of pulse, and slurring speech. 
CONCLUSIONS 
Carbon tetrachlorid is an effective drug in removing certain worms. 
It is especially valuable for removing bloodsucking strongyles. It has a 
rather high efficacy against ascarids in certain species of host animals. 
It may prove of value in removing whipworms from some kinds of 
animals if experience bears out the existing findings to the effect that 
large doses of the drug may be safely tolerated, making it possible to 
insure the entry of the drug into the cecum. It has some efficacy 
against heterakids in the large and small intestines. 
Enough evidence has accumulated in the published literature and in 
our experiments to warrant the statement that the efficacy of a drug 
against worms in the stomach can not be accurately ascertained by the 
technic employed by us, owing to the digestion of the dead worms in 
the stomach. It is evident that carbon tetrachlorid and some other 
drugs are highly effective against certain species of worms occurring in 
the lumen of the stomach, more effective than the evidence in worms 
passed indicates. 
Carbon tetrachlorid when taken by mouth, and the inhalation of the 
drug avoided, appears to be an uncommonly safe drug, for most of the 
species of animals tested. It appears that the danger from inhalation 
is greater for carnivores than for man. It has in most instances a 
large safety factor for the therapeutic dose necessary to remove approxi¬ 
mately ioo per cent of a number of important species of worm para¬ 
sites. This drug has the advantage of being a very simple compound, 
which can be easily tested chemically to determine its purity, and a 
chemically pure product can be purchased at practically any drug 
store in civilized countries. 
Carbon tetrachlorid has the additional advantage of being cheap. 
It is much cheaper than chenopodium or thymol, though not so cheap 
as the copper-sulphate solution for removing stomach worms from sheep. 
Its ioo per cent efficacy would appear to warrant further investigations 
as to its use against stomach worms of sheep, since the worms left by 
the copper-sulphate solution serve to maintain the infestation on pastures. 
Its value in this connection should also be weighed against that of the 
tobacco-copper-sulphate solution which Guberlet (8) finds superior to 
the copper-sulphate solution without tobacco. 
On a comparison of doses of carbon tetrachlorid based on weight of 
animal, the tolerance of the drug by the various species of animals used 
is about as follows: Chickens will tolerate 20 cc. per kilo, the minimum 
lethal dose not being ascertained, from which we may surmise that 
birds will prove very tolerant of this drug. Turkeys tolerate doses of 
1 cc. per kilo, and we may assume from the results with chickens that 
they will tolerate much higher doses. Dogs will tolerate 16 cc. per 
kilo, the minimum lethal dose not being ascertained. Cats will tolerate 
8 cc. per kilo, but some animals are killed by approximately 9 cc. per 
kilo. Foxes tolerate 2.7 cc. per kilo administered in a drench, and we 
may surmise that carnivores in general will prove very tolerant of this 
drug. Rabbits will tolerate 5 cc. per kilo, the minimum lethal dose 
apparently being close to 10 cc. per kilo, from which it appears that 
