Jan. ao, 1923 
Carbon Tetrachlorid as an Anthelmintic 
191 
rabbits, and probably the closely related group of rodents, will tolerate 
relatively large doses, but are not so tolerant as birds and some carni¬ 
vores. Monkeys will tolerate 6 cc. per kilo, the minimum lethal dose 
not being ascertained, and are therefore probably about as tolerant of 
the drug as rabbits. Adult swine will tolerate 1.66 cc. per kilo, but the 
tolerance is less for young animals, and swine are evidently less tolerant 
of carbon tetrachlorid than are the animals already referred to. The 
fact that swine are not more tolerant may be correlated with the common 
occurrence of hepatic cirrhosis in swine and the effect of the drug on 
the liver. Sheep will tolerate 1.3 cc. per kilo, but the minimum lethal 
dose may be about 2 cc. per kilo. Young cattle will tolerate 0.88 cc. 
per kilo, with an indicated minimum lethal dose of about 1.25 cc. per 
kilo. From the foregoing we may conclude that ruminants are less 
tolerant of this drug than are birds, carnivores, rabbits, monkeys, or 
swine, this decreased tolerance apparently agreeing with the ascertained 
diminished tolerance of ruminants for such volatile drugs as chloroform 
and probably being associated with the presence of the four stomach 
divisions of ruminants with a resultant rapid absorption of volatile 
drugs. The tolerance of approximately normal horses for carbon 
tetrachlorid is yet to be ascertained, since the animal which died 5 days 
after a dose of 0.12 cc. per kilo was an old, weak animal with pronounced 
lesions of a chronic nature. 
(1) 
(2) 
( 3 ) 
( 4 ) 
( 5 ) 
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(10) 
(11) 
LITERATURE CITED 
Allen, J. A. 
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Bakker, C. R. 
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Fitzgerald, W. H. 
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Amer. Fox and Fur Farmer, v. 1 (no. 12), p. 17. 
Floris, Rudolf. 
1907. A SZ^NKtoEG ALKALMAZASA A M^TELYKOR ELLEN. (CARBONEUM SUL- 
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Rev., v. 34, p. 242-243. 1908. 
Guberlet, John E. 
[1922]. STOMACH WORMS IN SHEEP. Okla. Agr. Exp. Sta. Bui. 137, 16 p., 5 fig. 
Literature cited, p. 16. 
Hall, Maurice C. 
1917. ANTHELMINTIC TREATMENT FOR NEMATODE INFESTATIONS IN DOGS. In 
Jour. Amer. Vet. Med. Assoc., v. 52 (n. s., v. 5), p. 342-345. 
1919. STUDIES ON ANTHELMINTICS. III. CHLOROFORM AS AN ANTHELMINTIC. In 
Jour. Amer. Vet. Med. Assoc., v. 55 (n. s., v. 8), p. 652-659. 
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