74 
ac veil as a qualitative ona in any case. 
Ths failure of th urogonitai inua derivatives generally, to be 
af'®o*!id ir exp intable either way. It uny b? due* either to lock of 
sunoepiibility t altered phy ological activity, sr to lack cf sus¬ 
ceptibility to the action of the specific horccne, possibly because 
pant the critical sia&» before the hormone b ;cttsc effective, in w Ich 
earlier introduction -i ht affect the , or to feein coapletely 
under sy otic control. 
vjen^rai changes in body idiupe and bah >vior betwe-.n tno two soxjb 
and frad-aiartin, while it i c...pable of satisfactory explanation on the 
basis of t\io qualitative specific iior»; no, io equally sc, on the bards 
HP a quantitative change i * ph>biological rreeti os initiated by the 
eey: hereto no, and work! g on tissues throughout the body, which react 
•pocifically t it in varying degree, depending on their own physio¬ 
logical conditions r lutiva tc it. 
(17) That the her one rust b© continuously passed to the frse- 
rariin to sustain the development or d*£«n ration, which it initiate?, 
would appear >012 tfc;> offoct of castration on th* general body ah pe 
of ‘he me' if 
aft 5 r castration a-, shewn for guin©a pi e by faB'nis (*0' ), Fisher (* ’3). 
They do no 1 null] i cattle feral es, and are pre uhiy . .v.ondent < 
the tcartic in rml and it would appear that It i expectir:. such to 
suppose that the ef ect on these and other atruetores in the free-jaartin 
is not dependent o« the tire the- hormone haa beer active cr that if the 
horaone has been active oni has initiated the development of the free- 
martin condition, that condition will develop to completion, if the 
bornone i* cut off before aucii completion it* arrived at, ev:n thou b h 
ite. threshold o " action ic low, ana, wnile present, it appears to follow 
the "all or none" law in action aa sug<eatea by billie (*21). 
. 
