24 
a-t  37°  C.  is  in  every  case  nearly  the  same,  vaiying  within  very  narrow 
limits,  hydrochloric  acid  and  sodium  hydrate  haemolysing  in  the 
concentration,  given  respectively  3,220  and  4,520  parts  by  weight  of 
TABi-t  to.  Haemolytiis  of  red  blood  cells  by  hydrochloric  acid  dissolved  in  o'g  per  cent. 
NaCl  solution.  Duration  of  experiment  three  hours.  Temperature  37°  C. 
Composition  of  Mixture  of  Red  Blood  Cells  and  Hydrochloric  Acid 
N'o.  of  I _ _ _ _ _ _ _ 
Experi¬ 
ment  Hydrochloric  acid  0-0041  % 
Weight  of  wet  red  cells  34-7 
Weight  of  hydrochloric  acid  i 
1 
0-0041  % 
72-9 
0-0041  % 
QI-I 
0*0041  % 
log 
0-0041  % 
127 
•  I 
I  Complete 
Complete 
Complete 
Slight 
Trace 
2  Complete 
Complete 
Complete 
Slight 
Trace 
3  ^  Complete 
Complete 
Complete 
Slight 
Tra.-:e 
wet  red  blood  cells  per  gramme-molecule  of  haemolytic  agent,  quinine 
in  the  alkaloidal  form  1,550)  micl  quinine  bihydrochloride  4,130  parts 
of  red  cells.  Quinine  in  the  alkaloidal  form,  as  already  mentioned,  is 
in  colloidal  solution  in  water.  The  low  figure,  which  it  gives,  as 
compared  with  hydrochloric  acid  and  sodium  hydrate,  which  are  in 
true  solution  and  nearly  completely  ionised,  may  possibly  be  in  part 
determined  by  the  physical  condition  of  hydrosol  in  which  the 
Table  ii.  Haemolysis  of  red  blood  cells  by  sodium  hydrate  dissolved  in  o'y  per  cent. 
NaCl  solution.  Duration  of  experiment  three  hours.  Temperature  37°  C. 
No.  of 
Composition  of  Mixture  of  Red  Blood 
Cells  and 
Sodium  Hydrate 
Experi¬ 
ment 
Sodium  hydrate  o'oc>45 
Weight  of  wet  red  cells  93 
Weight  of  sodium  hydrate  i 
0-0045  ”0 
'■3 
°-o°45  % 
"3 
0-0045  % 
'53 
0-0045  % 
173 
I 
1 
Complete 
Complete 
Marked 
Slight 
Trace 
2 
Complete 
Complete 
Almost 
complete 
Marked 
Trace 
3 
Complete 
Almost 
complete 
Marked 
Slight 
Trace 
alkaloidal  quinine  exists.  On  the  other  hand  quinine  bihydrochloride 
is  in  part  hydrolysed,  so  that  we  have  here  to  do  with  a  triple  effect, 
the  solution  being  in  reality  a  mixture  of  quinine  salt,  quinine  in  the 
