^0 
psi'  cent.,  and  the  percentage  of  quinine  in  the  free  state  0'035(S 
per  cent.  =  o'ooio8  M.  To  the  results  given  in  tire  second  and  third 
columns  the  formulae  for  bimolecular  and  multimolecular  reaction 
Table  13.  'i'hc  rate  of  haemolysis  of  red  blood  cells  by  a  0*03  58  %  solution  of  quinine 
in  0*9%  solution  of  sodium  chloride.  The  ratio  of  the  weight  of  wet  red  cells  to  the 
amount  of  quinine  present  is  r2’6  ;  i.  Temperature  of  experiment  37°  C. 
'Time 
Concentration  of 
Same  in  percentage 
1 
wet  red  cells 
of  0*476 
c; 
^0 
0  min. 
0-476  «■„ 
100*0 
h 
50  ., 
0-432% 
(jO'S 
0‘000i) 
h 
80 
0-396  % 
8  2-0 
0*001  I 
h 
I  ro  ,, 
o’.U'  "0 
7'7 
0*001 
<1 
140 
0-258% 
i4--! 
0*00  iq 
h 
170  ,, 
0-188% 
0*0024 
200 
0-146% 
30-7 
0*002  I 
/j 
230 
0-074  % 
21*2 
0*0029 
^8 
260  ,, 
0-029  0;, 
6-1 
0*0047 
1 
Mean  0*0022 
rates  were  applied,  but  the  values  of  K  obtained  were  so  divergent 
that  these  two  reaction  rates  may  be  excluded  from  consideration. 
In  Table  13  the  reaction  rate  constant  for  monomolecular  reactions, 
is  calculated  in  the  last  column  The  values  obtained 
range  between  o'ooog  and  o'ooqy,  the  mean  being  0'0022.  The 
variations  in  the  value  of  K  are  greatest  at  the  beginning  and  end  of 
the  process  of  haemolysis,  being  low  at  the  former  and  high  at  the 
latter.  If,  however,  the  period  tg  to  t.^  is  alone  considered,  the 
variations  are  much  less,  and  during  this  period  the  reaction  follows 
fairly  closely  a  monomolecular  rate. 
Table  14.  Reaction  rate  constant  of  the  experiments  recorded  in  Table  13  recalculated. 
Concentration  of 
Same  in  percentage 
1 
log 
^11  1  J 
Time 
wet  red  cells 
of  0*476 
hi  '  1“ 
0  min. 
0-476  % 
100*0 
?o  „ 
0-432  % 
qo-8 
0*0009 
1-2 
80  „ 
0-396% 
82-0 
0*0015 
h 
no  „ 
0-34I  % 
71-7 
0*0019 
1 
u 
140 
0-238  % 
34-2 
0*0040 
Mean 
h 
170  .. 
0-188  % 
39-5 
0*0045 
^  h  to  /, 
^6 
200  ,, 
0-146% 
30-7 
0-0037 
0-0039 
h 
2.8°  „ 
0-074  % 
21*2 
0*0054 
) 
h 
260 
0-029 
6*1 
0*0183 
