AN  INVESTIGATION  INTO  THE 
MECHANISM  OE  PRODUCTION  OE 
BLACKWATER 
BY 
J.  O.  WAKELIN  BARRATT,  M.D.,  D.Sc.,  Lond., 
AND 
WARRINGTON  YORKE,  M.D,  Liverpool 
{Being  the  Report  of  the  Blackwaier  Fever  Expedition  to  Nyasaland 
of  the  Liverpool  School  of  Tropical  Medicine,  1907-1909) 
{Received  for  publication  6  May,  1909) 
CONTENTS 
Introduction,  p.  12. 
Section  I.  The  haemolysis  of  red  blood  cells  by  cjuinine  and  also  by  acid,  alkali 
and  urine. 
(a)  Action  of  quinine,  acid  and  alkali  on  healthy  red  blood  cells  : 
action  of  quinine  bihydrochloride  in  varying  concentrations  on  red 
blood  cells,  p.  13  ;  action  of  quinine  in  the  form  of  alkaloid  on  red 
blood  cells,  p.  19  ;  action  of  hydrochloric  acid  on  red  blood  cells,  p.  20  ; 
action  of  sodium  hydrate  on  red  blood  cells,  p.  21  ;  action  of  quinine, 
hydrochloric  acid  and  sodium  hydrate  on  red  blood  cells  compared, 
p.  22  ;  nature  of  the  action  of  quinine  in  alkaloidal  state  on  red  blood 
cells,  rate  of  action  of  alkaloidal  quinine,  value  of  yit,  comparison  with 
pepsin,  amount  of  quinine  taken  up  by  red  blood  cells,  p.  27  ;  action 
of  quinine  on  healthy  red  blood  cells  in  the  living  body,  p.  42. 
{b)  Action  of  quinine  on  red  blood  cells  during  blackwater  fever, 
p.  44.. 
