6o 
when  /X  —  13,600;  in  the  former  case  a  reduction  of  the  temperature 
of  37°  C.  by  one  degree  leads  to  a  reduction  of  the  rate  of  destruction 
from  I  to  0'855,  and  in  the  latter  case  from  i  to  0'g25.  The  same 
relationship  may  be  stated  in  another  way  :  the  rate  of  destruction 
of  haemoglobin  at  37°  C.  becomes  reduced  to  one  half  when  the 
temperature  is  lowered  5°  C.  if  /i  =  30,000,  and  when  the  tempera¬ 
ture  is  lowered  g°  C.  if  /i  13,600.  These  values  are  nearl)’  the 
same  as  those  obtaining'  m  the  actual  experiments. 
T.^bt.k  2S.  Comparison  of  valuc.s  of  K  at  different  temperatures.  Cp.  Table  27. 
T 
I 
Nn.  of  Experiment 
^  3 
fl  -30,000 
I 
Calculated  for 
24.100  19,400 
2  ’ 
1 3,fio- 
4 
.17°  c. 
0’005 1 
0*0021  0*0043 
0*00032 
0*0044 
0*0024 
0*0039 
0*00026 
31°  c. 
0*001  7 
0*0011  0*0021 
0*00017 
0*0017 
0*001  r 
0*002  I 
0*000 1 7 
25»C. 
o*ooo8 
0*00038  0*00079 
0*00013 
0’00o6 
0*00037 
o*ooo88 
o*ooooqz 
It  is  thus  seen  that  m  the  presence  of  urine  the  rate  of  destruction 
of  haemoglobin  contained  in  red  blood  cells  resembles  that  of  a 
monomolecular  process,  and  is  in  this  respect  similar  to  the  rate  of 
haemolysis  of  red  blood  cells  in  the  presence  of  quinine  in  the 
alkaloidal  state  (Tables  13  to  ig).  The  two  processes  are,  however, 
of  a  different  character,  the  foimer  being  apparently  a  direct  action 
upon  haemoglobin,  while  the  latter  seems  to  be  the  result  of  an  action 
directed  primarily  to  the  stromata  of  the  red  blood  cells. 
SUMMARY 
The  principal  points  in  the  above  investigation  may  be 
summarised  as  follows  ;  — 
I.  Quinine  bihydiochloride  and  quinine  m  the  alkaloidal  state 
produce  haemolysis  of  red  blood  cells,  as  do  also  hydrochloric  acid 
and  sodium  hydrate. 
2.  The  action  of  quinine  in  the  alkaloidal  state  in  producing 
haemolysis  resembles  a  catalytic  action. 
