()I 
3.  Haernog-lobin  breaks  up  at  a  monomolecular  rate  under  the 
action  of  quinine  in  the  alkaloidal  state. 
4.  The  above-mentioned  four  haemolytic  agents  possess,  in 
equimolecular  concentration,  nearly  the  same  haemolytic  power, 
quinine  in  the  alkaloidal  state  being  weaker,  and  quinine  bihydro¬ 
chloride  stronger  than  hydrochloric  acid  and  sodium  hydrate,  which 
occupy  an  intermediate  position. 
5.  Owing  to  the  toxicity  of  quinine  its  concentration  in  the  blood 
cannot  reach  an  amount  sufficient  to  allow  of  its  direct  haemolytic 
action  on  red  cells  taking  place  during  life. 
6.  Ihe  red  blood  cells  during  blackwater  fever  are  not 
haemolysed  by  quinine  bihydrochloride  more  readily  than  in  health. 
7.  In  the  presence  of  urine  haemoglobin,  whether  contained  in 
red  blood  cells  or  in  solution,  is  broken  up.  In  the  former  case  this 
proceeds  at  a  monomolecular  rate,  no  haemoglobin  being  discharged 
from  the  red  cells  into  the  urine,  until  destruction  is  nearly  complete. 
8.  The  constant,  n,  for  the  haemolysis  of  red  blood  cells  was 
found  to  have  a  mean  value  of  15,000  for  a  0-00113  solution  of 
alkaloidal  quinine.  The  value  of  /i  for  the  destruction  of  haemo- 
globin  in  the  presence  of  urine  ranged,  in  the  experiments  made, 
from  13,000  to  30,000.  The  values  of  ranged  in  the  former 
cases  from  o  0026  to  o'OoS/,  and  in  the  latter  case  from  0-0026  to 
0-0039. 
