92 
haemoglobin  and  plasma  employed  were  those  of  Rabbit  5,  Tables 
35  37:  in  Experiment  3,  those  of  Rabbit  6,  Tables  35  and  3; 
In  all  three  experiments  the  disappearance  of  lakcd  haemoglobin 
took  place  very  slowly,  compared  with  that  occurring  in  the  living 
body,  less  than  30  per  cent,  being  broken  np  in  six  and  a  half  hours, 
No  data  are  available  to  indicate  the  rate  at  which  in  the  circnkiting 
blood,  destruction  is  effected  solely  by  the  plasma,  nor  do  our  expcri- 
menls  permit  any  conclusion  to  be  drawn  as  to  the  part  jdayed  by  the 
bod)'  (issues  in  the  remoxail  of  haemoglobin,  I  he  disappearance  of 
the  dissolved  haemoglobin  is  also,  to  a  small  extent,  affected  by  (hp 
action  of  the  kidneys.  To  what  extent  this  affects  the  percentage 
present  in  the  blood  plasma  cannot  he  precisely  determined,  since  il 
IS  unknown  how  far  the  amount  of  water  leaving  the  blood  to  pass 
through  the  kidneys  is  replaced  by  water  absorbed  from  (he  contents 
ot  the  stomach  and  intestines. 
SUMMARY 
1  he  principal  points  in  the  foregoing  may  be  summed  up  as 
follows  :  — 
1.  In  oxalated  blood  |)la.sma  obtained  from  healthy  individuals, 
O' 10  per  cent.,  or  less,  to  as  much  as  0-25  per  cent,  of  dissolved  haemo¬ 
globin  was  found  ;  in  oxalated  blood  pla.sma  obtained  during  black 
watei  fever,  while  the  urine  in  the  bladder  still  contained  haemo¬ 
globin,  the  amount  of  dissolved  haemoglobin  was  usually,  but  not 
always,  greater  than  this,  ranging  between  0-30  per  eent.  and  O'p) 
per  cent. 
2.  Ilaemoglobinaemia  produced  experimentally  in  the  rabbit  is 
accompanied  by  haemoglobinuria,  the  percentage  of  haemoglobin  in 
the  urine  quickly  surpassing  that  in  the  blood  plasma  (Experiments 
S-io,  Table  35),  and  subsequently  falling  as  the  latter  diminished. 
3.  The  disappearanee  of  dissolved  haemoglobin  from  the  blood 
plasma  proceeds  in  the  living  body  of  the  rabbit  at  approximately 
the  same  rale  as  a  monomolecular  chemical  reaction. 
