97 
not,  but  when  a  little  methylene  blue  solution  was  added  these  masses 
could  be  recognised  to  be  nuclei  resembling  those  of  the  epithelial 
cells  of  the  renal  tubule,  from  which  they  obviously  arose.  The  casts 
varied  considerably  in  length,  being  from  20/1  to  as  much  as  400  jx 
long,  their  diameter  ranging  from  3  to  30  or  more  (Figs.  21 
to  24).  The  size  of  the  degenerated  nuclei  ranged  from  7  m  to  12  m- 
The  nuclei  were  usually  very  few  in  number,  but  occasionally  became 
numerous,  the  casts  then  becoming  epithelial  casts  (Figs  22,  24). 
Free  epithelial  cells  with  degenerated  nuclei  were  also  found,  some¬ 
times  singly,  sometimes  in  groups  of  two  and  three,  in  the  latter  case 
forming  a  transitional  condition  between  single  free  cells  and 
epithelial  casts.  All  the  free  cells  met  with  in  the  haemoglobinous 
urine  of  Experiments  I  to  lO,  Tables  35  to  39,  were  of  spheroidal 
form,  and  appeared  to  be  derived  from  the  uriniferous  tubules.  The 
urine,  when  examined  before  the  injection  of  haemoglobin,  was 
always  free  from  cells.  The  amount  of  solid  matter  contained  in  the 
haemoglobinous  urine  in  these  experiments  was  very  variable 
(Table  39),  being  sometimes  very  small,  sometimes  abundant,  forming 
on  standing  a  precipitate  of  as  much  as  a  sixth  of  a  column.  This 
variation  appeared  in  Experiments  9  and  10  (Figs.  8  and  9)  to  be 
'I'able  39.  Characters  of  deposit  from  urine  of  rabbit  during  haemoglobinuria  experi¬ 
mentally  induced.  Cp.  Tables  35  and  37. 
No  of 
Experi¬ 
ment 
Colour 
Amount 
Microscopic  characters 
I 
Brown 
Very  small 
No  casts 
2 
Browir 
Very  small 
Hyaline  casts  with  here  and  there  fine  granules 
(Fig.  21) 
3 
Greyish 
black 
Very  small 
Granular  casts  (large  and  fine  granules),  very  few 
renal  epithelial  cells  (Fig.  22) 
4 
Chocolate 
coloured 
Abundant  col.) 
Granular  casts  (large  and  fine  granules)  and  granular 
debris 
5 
— 
N^ery  small 
Clranular  casts  (large  and  tine  granules)  and  hyaline 
casts  (Fig.  23) 
6 
Chocolate 
coloured 
Abundant  col.) 
Granular  casts  (coarse  and  fine  granules),  free 
granules,  renal  epithelial  casts  (Fig.  24) 
7 
Chocolate 
coloured 
Small 
Granular  casts  and  free  granules 
8 
— 
Small 
Granular  and  renal  epithelial  casts 
9 
Chocolate 
coloured 
.'\bundant  (J  col.) 
Granular  casts  and  renal  epithelial  cells 
10 
Chocolate 
coloured 
Abundant  (J  col.) 
Granular  casts  and  renal  epithelial  cells 
G 
