123 
tubules  was  wide,  but  there  was  not  the  marked  distension  with 
flattening  and  thinning  of  the  epithelial  lining  seen  in  the  two 
preceding  cases.  The  interstitial  tissue  showed  no  cell  infiltration, 
nor  was  any  recognisable  increase  of  connective  tissue  present.  No 
evidence  of  renal  haemorrhage  was  found,  and  the  blood  vessels 
were  free  from  malarial  pigment,  ft  will  thus  be  seen  that  the 
chief  points  of  difference,  as  regards  the  condition  of  the  kidneys, 
between  this  case  (i6)  and  the  preceding  cases  (ya  and  ii),  in  which 
suppression  of  urine  occurred,  are  :  the  absence  of  distension  of  the 
renal  tubules  in  degree  sufficient  to  cause  flattening  and  thinning  of 
I  I - 1 
OjM  300  jX 
1‘1G.  47.  Longitudinal  section  of  medulla  of  kidney  during  experimental 
haemoglobin uria.  Rabbit  7,  Table  35.  In  four  of  the  large  collecting 
tubules  granular  casts  are  seen  partly  occupying  the  lumen  of  these 
tubules.  The  granules  are  fine,  but  vary  somewhat  in  size  and  also 
in  number  in  different  situations.  In  addition  some  slightl)''  staining 
flocculent  material  is  observable  in  the  tubules.  The  renal  epithelium 
IS  healthy  and  the  tubules  are  not  dilated.  No  change  is  present  in  the 
interstitial  tissue.  A  few  of  the  blond  capillaries  contain  red  cells 
darkly  stained.  Hardened  in  alcohol.  Stained  with  iron  alum  haema- 
toxylin.  X  170. 
