124 
the  epithelial  lining  ;  the  frequency  with  which  small  granules,  2/i  to 
less  than  0'5M  in  diameter,  were  met  with;  and  the  much  greater 
extent  to  which  the  renal  epithelial  cells  were  loosened  and  detached. 
The  condition  of  the  kidneys  of  the  rabbit  in  experimental 
haemoglobinuria  was  also  studied.  In  illustration  of  the  changes 
observed,  we  give  sketches  of  sections  made  :  during  haemoglobinuria 
(eighty-five  minutes  after  the  injection  of  dissolved  haemoglobin, 
Experiment  7,  Table  35),  Figs.  45-49  and  59-60;  twenty-two  hours 
after  injection  and  fourteen  hours  after  cessation  of  haemoglobinuria 
(Experiment  9,  Table  35),  Figs.  50-51. 
Kig.  48.  Section  of  cortex  of  kidney  during  experimental  haemoglobinuria. 
Rabbit  7,  Table  35.  A  convoluted  tubule  is  shown  in  longitudinal 
seotion,  containing  a  granular  cast,  which  does  not  completely  fill  the 
lumen  of  the  tubule,  the  intervening  space  being  occupied  by  hyaline 
material  in  which  the  cast  is  embedded.  .\t  each  extremity  of  the 
cast,  and  near  its  centre,  the  individual  granules  become  distinct  and 
have  a  diameter  of  i/i  to  2fi;  elsewhere  they  are  packed  together  so 
densely  that  their  individual  outlines  become  uni-ecognisable.  The 
cytoplasm  of  the  renal  tubules  presents  a  finely  granular  aspect. 
Below  two  entire  red  blood  cells  and  part  of  three  others,  .stained 
black,  are  shown.  Hardened  in  alcohol.  Stained  with  iron  alum 
haematoxylin.  x  1250. 
In  each  case  the  naked  eye  aspect  of  the  kidneys  presented  no 
obvious  change  from  the  normal,  the  colour  of  the  kidney  being 
unaltered,  the  pyramid  natural  in  appearance,  and  no  brown  stippling 
