194 
3rd  day.  In  the  murning  patient’s  temperature  was  not  raised 
p'elt  fairly  well,  except  for  an  empty  feeling  at  the  stomach  and  a 
sense  of  weakness.  In  the  afternoon  vomited  several  time.s,  and  in 
the  evening  had  a  temperature  of  104  h.  Noticed  that  his  urine  was 
somewhat  high  coloured,  but  this  he  did  not  think  unusual.  Took 
fifteen  grains  of  quinine,  in  five-grain  doses,  during  the  day. 
4th  day.  Noticed  that  his  colour  was  sallow,  and  on  passing  his  ||, 
urine  observed  that  it  resembled  stout,  being  dark  coloured.  Has 
pain  in  the  hypogastric  region.  Has  had  pain  in  loins  for  last  three 
days,  but  no  general  pains,  as  rvas  the  case  during  the  previous  attack 
of  blackwater  fever.  No  constitutional  disturbance.  Temperature 
normal.  The  viscera  appear  healthy.  No  recognisable  enlargement 
of  the  spleen.  Is  anaemic  and  sallow. 
5th  day.  Urine  amber  coloured.  General  condition  good. 
Appetite  fair.  Temperature  normal. 
Recovery  was  uninterrupted,  no  relapse  occurring. 
Condiiion  of  blood.  4th  clay,  12-30  p.m.  Blood  plasma  of  dark 
orange  colour,  no  reddish  tint  being  observable  ;  gives  faint  oxy- 
haemoglobin  bands  in  a  column  eighteen  millimetres  high,  0  13  per 
cent,  of  dissolved  haemoglobin  being  present ;  no  autolysin  present 
The  following  observations  were  made  at  37°  C.  with  the  patient- 
red  blood  cells  suspended  in  O’g  per  cent,  sodium  chloride  solution,  to  j 
which  quinine  bihydrochloride  had  been  added. — 
No.  of 
Composition  of  Mixture  of  Reo  Blood  Cells  and 
Quinine  Solution. 
Haemolysis. 
ment. 
2*5  %  emulsion  of 
red  blood  cells. 
0*9  %  solution  of 
sodium  chloride. 
1-92  %  solution  of 
quinine  bihydro¬ 
chloride. 
0'2  c.c. 
1*2  c.c. 
o.i  c.c. 
Complete  nt  end  of  3)'' 
2 
0*5  c,c. 
2*4  c.c. 
0*1  c.c. 
Complete  at  end  ofiU 
3 
+ 
1*05  c.c. 
1*7  c.c. 
4*6  c.c. 
7*2  c.c. 
0*1  c.c. 
0*T  c.c. 
I*artial  at  end  of  3  Wi' 
Unaffected  at  end  of 
7th  day.  Blood  smear  negative. 
8th  day.  Blood  plasma  of  light  orange  colour,  contains  aWl 
0'06  per  cent,  of  dissolved  haemoglobin. 
