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able  amount  of  fever,  but  has  never  previously  had  blackwater  fever, 
Mas  rarely  taken  quinine  except  after  an  attack  of  fever. 
He  commenced  to  be  ill  with  fever  three  days  ago.  Stayed  in  bed 
and  took  fifteen  grains  of  quinine  on  this  and  on  each  of  the  two 
following  days. 
4th  day.  At  2  p.m.  he  had  a  rigor,  T.  I04'4°F.,  and  shortly 
afterwards  passed  porter  coloured  urine.  Had  slight  vomiting. 
5th  day.  Patient  felt  better  this  morning.  The  vomiting  had 
ceased,  and  the  urine  during  the  morning  became  almost  clear.  About 
noon  the  urine  became  red  again.  At  2-30  p.m.  T.  102°  F.  Vomiting 
was  troublesome.  The  spleen  was  enlarged  and  easily  palpable. 
f)th  day.  Patient  better  to-day.  Urine  amber  coloured.  At 
10  a.m.  three  grains  of  quinine  bihydrochloride  were  given  hypo¬ 
dermically,  and  at  2  p.m.  two  and  a  half  grains  were  given  by  the 
mouth. 
/th  day.  About  noon  to-day  there  was  a  slight  relapse,  the  urme 
becoming  claret  coloured.  One  grain  of  quinine  was  given  thiee 
times  to-day. 
8th  day  to  13th  day.  Quinine  bihydrochloride  was  administered 
thrice  daily  in  two  grain  doses.  The  urine  remained  amber  coloured 
during  this  period. 
14th  day.  Three  grains  of  quinine  bihydrochloride  were  given 
thrice  daily. 
15th  day.  Patient  remained  well,  no  further  relapse;  the  urine 
continued  to  be  amber  coloured. 
Condi/ ion  of  blood.  5th  day.  At  1-45  p.m.  patient’s  oxalated 
plasma  was  of  a  deep  orange  colour,  with  no  red  tint,  containing 
0-13  per  cent,  of  haemoglobin.  No  bands  of  methaemoglobin  were 
seen  on  examining  a  column  of  the  plasma  1 8  mm.  deep.  N® 
