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gth  (lay.  The  urine  was  coloured  ajjain  this  mornini^,  but  cleared 
u]i  111  the  evening.  Quinine  bih^-drochloride  was  given  as  before  in 
two  doses  of  two  and  a  half  grains  each.  T.  102°  !•’. 
loth  day.  The  urine,  which  was  clear  this  morning,  became 
deeply  red  coloured  about  mid-day.  Quinine  bihydrochloride  was 
given  in  solution  in  three  doses  of  three  and  three  quarter  grains 
each.  T.  104°  F.  Patient  appeared  to  be  in  fairly  good  condition. 
nth  day.  The  urine  remained  clear  all  day.  Quinine  bihydro 
chloride  was  given  in  three  doses  of  five  grains  each.  T.  ioo-6°  F. 
1 2lh  day.  There  was  another  slight  relapse  this  morning.  Quinine 
bihydrochloride  was  given  again  in  three  doses  of  five  grains  each 
T.  103°  F. 
13th  day.  The  urine,  which  had  become  amber  coloured 
yesterday  afternoon,  was  again  red  about  noon  to-da}’.  Quinine 
bihydrochloride  was  given  in  three  doses  of  five  grains  each. 
T.  102° F. 
14th  day.  There  was  a  slight  brownish  coloration  of  the  urine 
about  noon  to-day,  but  no  detectable  amount  of  haemoglobin.  No 
quinine  was  given  to-day.  T.  103°  F. 
15th  day.  Urine  normal  all  day.  No  quinine  given.  T  101°  F. 
iGth  day.  Urine  normal.  No  quinine  given.  T.  I00‘4°  F. 
Patient  remained  welt  and  had  no  further  relapses.  About 
fourteen  days  later  small  doses  of  quinine  were  commenced  and  the 
quantity  gradually  increased  until  fifteen  grains  were  given  daily. 
No  further  relapses  occurred 
Condition  of  blood. — ■2nd  day.  At  ii  a.m.  patient’s  o.xalated 
plasma  was  of  a  deep  orange  colour  with  a  distinct  reddish  tint,  and 
gave  marked  bands  of  oxyhaemoglobin  in  a  column  18  mm.  high, 
representing  0-85  per  cent,  of  dissolved  haemoglobin.  Faint  bands 
of  methaemoglobin  were  visible.  No  autolysin  was  present  in  the 
serum,  and  no  parasites  or  pigmented  leucocytes  were  found  in  the 
blood.^  The  following  observations  were  made  at  37°  C.  with  the 
patient’s  red  blood  cells  suspended  in  o-g  per  cent,  sodium  chloride 
solution,  to  which  quinine  bihydrorhloride  had  been  added. 
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