jnd  day.  Patient  felt  rather  better  to-day.  T.  Qcy6°  F.  .Spleen 
slifjhtly  enlarged  and  just  palpable  below  co.stal  margin.  Xo 
\’omiting. 
3rd  day.  Patient  appeared  well  to-day.  The  temperature  was 
normal,  and  the  urine  amber  coloured.  Quinine  sulphate  in  solution 
was  given  in  three  doses  of  one  grain  each. 
4th  day.  Quinine  was  given  as  above  in  three  doses  of  two 
grains  each. 
5th  day.  Three  doses  of  three  grains  of  quinine  were 
administered  to-day.  The  patient  continued  well ;  there  was  no 
relapse  of  the  blackwater. 
6th  day.  Three  doses  of  four  grains  of  c[uinine  were  given 
to-day. 
7th  day.  From  to-day  the  patient  took  five  grains  of  quinine 
three  times  daily.  The  patient’s  recover)'  was  uninterrupted. 
Condition  of  blood.-  -inC  day.  At  4-30  p.m.  patient’s  oxalated 
plasma  was  of  a  dark  orange  colour.  It  gave  distinct  oxyhaemo- 
globin  bands,  o'2  per  cent,  of  haemoglobin  being  present  in  solution. 
On  examining  with  the  aid  of  the  haeniocnt,  the  blood  was  found  to 
contain  33  per  cent,  by  volume  of  red  cells.  On  testing  for 
haemolysin  complete  haemolysis  occurred,  but  the  plasma,  which  had 
been  kept  for  twenty-four  hours,  was  found  to  contain  a  considerable 
number  of  bacteria.  No  malarial  parasites  or  pigmented  leucocytes 
were  found  in  the  blood. 
3rcl  day.  At  10-30  a.m.  patient’s  oxalated  plasma  was  of  an 
amber  colour.  It  gave  faint  oxyhaemoglobin  bands,  when  e.xamined 
ill  a  column  eighteen  millimetres  high,  o'l  per  cent,  of  haemoglobin 
being  present  in  solution.  No  autol)'sin  was  present,  and  no  malarial 
parasites  or  pigmented  leucocytes  were  found  in  the  blood. 
Condition  of  the  spleen.  2nd  day.  At  4-30  p.m.  a  spleen 
puncture  was  made.  Phagocytosis  of  red  cells  (by  about  3  per  cent, 
of  white  cells)  was  observed.  No  malarial  parasites  or  pigment 
found. 
3rd  da)c  At  10-30  a.m.  a  spleen  puncture  was  made.  Phago¬ 
cytosis  of  red  cells  (by  about  3  per  cent,  of  white  cells)  was  observed. 
No  malarial  parasites  or  pigment  found. 
