235 
Subsequent  specimens  of  the  urine  were  amber  coloured  and 
normal. 
Male,  thirty-five  years  of  age.  Cook.  Indian.  • 
Has  lived  in  Nyasaland  for  four  years,  and  during  this  time  has 
had  a  good  deal  of  fever,  but  this  has  not  often  been  so  severe  as  to 
necessitate  his  giving  up  work.  Has  never  previously  had  blackwater 
fever.  Has  not  taken  quinine  regularly.  He  began  to  be  ill  with 
fever  and  headache  four  days  ago.  Quinine  bihydrochloride  was 
given  in  solution  in  doses  of  five  grains  three  times  daily.  He 
continued  to  take  this  solution  of  quinine  in  similar  doses  during  the 
next  three  days. 
1st  day.  Patient  passed  blackwater  this  morning.  He  was 
obviously  very  ill,  vomiting  incessantly.  The  skin  and  conjunctivae 
were  yellowish.  T.  ior6°F.  Pie  had  considerable  diarrhoea,  and 
during  the  day  he  passed  six  black  tarry  stools  and  stated  he  had 
been  passing  similar  stools  for  the  past  three  or  four  days. 
2nd  day.  PLs  condition  was  unchanged.  The  spleen  could  just 
be  felt  below  the  costal  margin. 
