affecting-  the  larger  corpuscles,  but  the  occurrence  of  nucleated  red 
corpuscles  is  a  very  rare  phenomenon. 
With  regard  to  the  white  cells,  a  definite  leucopenia  has  always 
been  found  during  what  may  be  called  the  hospital  phase  of  the 
disease.  Thus,  the  average  leucocyte  count  in  the  series  of  cases 
examined  was  4,503  per  cubic  mm.,  and  the  percentage  proportions 
of  the  main  varieties  of  leucocytes  present,  calculated  from  a  series 
of  differential  analyses,  gives  the  following  figures  :  — 
Polymorphonuclear  neutrophiles  .  62-84 
Lymphocytes  .  25-26 
Large  lymphocytes  and  hyaline  cells  .  5‘50 
Eosinophiles  .  6-40 
100-00 
Mast-cells  are  usually  present,  but  seldom  exceed  the  normal 
limit  of  0-5  per  cent.  Neutrophile  myelocytes  were  noted  in  a  small 
proportion  of  the  cases,  but  never  exceeded  O'  5  per  cent. ;  for  the 
sake  of  simplicity,  therefore,  these  two  classes  of  cells  have  been 
omitted  from  the  composite  table.  It  will  thus  be  seen  that  the 
polymorphonuclear  cells  are  relatively  diminished,  while  the  propor¬ 
tions  of  the  other  classes,  and  particularly  of  the  large  hyalme  cells 
and  eosinophiles,  are  distinctly  increased.  A  certain  degree  of 
eosinophilia  is  of  such  frequent  occurrence  in  Egypt,  as  the  result  of 
Bilharzial  or  Ankylostomal  infections,  that  this  feature  of  the  blood 
formula  may  be  at  once  discounted. 
The  bone-maiTOW  has  always  been  found  more  or  less 
profoundly  affected.  That  of  the  ribs  is  almost  always  diffluent, 
its  colour  varying  with  the  degree  of  anaemia.  The  femur 
always  manifests  an  active  transformation  of  its  marrow;  in  some 
cases  this  is  of  a  reddish  gelatinous  character,  and  in  others  it  is  of 
deep  red  colour  and  firm  consistence,  resembling  in  appearance  that 
of  pernicious  anaemia.  In  both  situations  the  hyaline  non-granular 
elements  of  the  marrow  are  very  notably  increased,  the  majority  of 
the  cells  being  of  the  dimensions  of  a  large  lymphocyte  with  pale 
staining  nucleus  of  simple  spherical  form.  The  relative  reduction  of 
the  granular  cells  of  the  marrow,  particularly  of  the  neutrophile 
variety,  is  sometimes  a  marked  feature,  and  is  most  noticeable  in 
