/.95 
BlO-CHEMlCAL  AND  THERAPEUTICAI 
STUDIES  ON  TRYPANOSOMIASIS 
nv 
ANTOX  BRlvlNL  AM)  .M.  X lERliXSTRlX 
front  /he  Runcorn  Research  Laboralorics  of  the  Liverpool  Schoool 
of  Tropical  Medicine 
{Received  for  pnblication  15  Angus/,  1909) 
CONTEXTS. 
I'AGE 
Introduction  . 39^ 
Organic  arsenic  compounds  .  39^ 
A.  Atoxyl  .  399 
II.  Derivatives  of  Atoxyl  . 403 
C.  Orsudan  .  40O 
D.  Derivatives  of  Orsudan  .  40S 
Colouring  matters  . 409 
Antimony  compounds  . 412 
The  regularity  of  the  time  of  re-appearance  of  parasites  after 
treatment  . 41' 
Value  of  subinoculations . 41" 
When  can  an  animal  be  considered  to  be  cured? .  418 
Comparative  value  of  experiments  on  different  laboratory  animals  420 
The  following  is  a  detailed  report  of  our  observations  on 
experimental  Trypanosomiasis,  the  treatment  of  infections  with 
different  pathogenic  trypanosomes,  and  the  mechanism  of  the 
therapeutical  action  of  various  trypanocidal  compounds.  The  experi¬ 
ments  were  carried  out  in  this  laboratory  during  the  last  two  years. 
Our  thanks  are  due  to  Sir  Alfred  Jones,  through  whose  generosity 
we  were  able  to  extend  our  experiments  upon  monkeys.  Further,  we 
wish  to  express  our  indebtedness  to  iMessrs.  Burroughs,  Wellcome 
and  Co.,  who  .supplied  us  with  a  great  number  of  trypanocidal  drugs 
and  supported  the  work  very  materially.  \\T  also  have  to  express  our 
thanks  to  Professor  Ehrlich  for  the  supply  of  different  compounds 
prepared  in  his  laboratory,  and  to  Messrs.  Bayer  and  Co.  who  put  at 
our  disposal  a  number  of  aniline  dyes  for  our  experimental  work. 
