405 
up  into  freo  p-umino-phonyl-arsenic  acid,  and  that  the  latter,  together 
with  an  amino  group  in  statu  nascendi,  might  have  a  greater  affinity 
for  the  serum  pioteins  and  combine  with  them  to  a  larger  extent. 
Experiments,  however,  have  shown  that  this  process  does  not  take 
place  in  the  organism,  as  even  large  doses  had  no  appreciable  effect  on 
rats  infected  with  trypanosomes, 
6.  Tetra  sodium  phenazine  4-arsenate. 
The  destructive  effect  of  phosphine,  a  colouring  matter  of  the 
safranine  type,'"  on  Parmuaeciinn  is  very  marked,  and  is  not 
surpassed  by  any  other  substance.  We,  therefore,  hoped  that  on 
combining  an  arsenic  molecule  with  a  phenacine,  a  colouring  matter 
of  the  same  type,  the  result  would  be  a  compound  of  increased 
trypanocidal  value  in  comparison  with  Atoxyl.  Experiments, 
however,  proved  that  this  compound  did  not  affect  trypanosomes. 
Reference  may  here  be  made  to  the  work  of  Mannaberg,t  who  finds 
that  phosphines  have  no  beneficial  effect  in  the  treatment  of  Malaria. 
.Sodium  di-p-amino-phenyl-arsenate 
and  Sodium  di-p-acetyl-amino-phenyl-arsenate. 
These  compounds,  even  if  used  in  the  largest  doses  which  could 
be  administered,  were  of  no  value  in  the  treatment  of  rats  infected 
with  T.  equiperdurn. 
t  rankel  M.  Die  Arzneimittelsynthese  aiif  Grunclla^e  der  Beziehg.  zwischen 
chemischen  Aufbau  iind  Wirkung.  2.  Aufl.,  1906,  p.  206. 
t  Mannaberg.  Arch.  f.  klin.  Medizin,  Ud.  59,  p.  185, 
