370 
EDITORIAL. 
a great oscillation in the temperatures of these animals was 
observed, oscillations which indicated only their febrile condi¬ 
tion. After the eighth day, in a few a gland was noticed which 
assumed the characters found in the glanderous animal. 
On December 15th, all the animals received an injection of 
malleine. This was followed in all by a thermic and local re¬ 
action, with swelling, general prostration, loss of appetite, etc. 
With some animals, these manifestations lasted a few days, but 
subsequently all returned to a normal condition in a variable 
length of time. 
A month later, in January, another injection of malleine was 
followed with the same reactions ; however, in a few this was 
marked zvith less severity. On January 21st, the third month 
of the experiment, three horses presented such external clinical 
symptoms that further experiment was useless, and they were 
destroyed. The disease given by contagion through the diges¬ 
tive canal was doubly made evident by the appearance of the 
symptoms and by the facts recorded by the use of malleine. 
Later on two more animals had the same ending. 
* 
^ * 
The injections of malleine were kept up every month until 
July, and from the third month a change was observed in the 
thermic reaction. With some animals it only diminished, with 
others there was none. The records of the temperature shown 
by the maps exhibited by Prof. Nocard were of great interest, in 
following the changes which were evidently going on in the 
subjects of the experiments. One of the animals, after remain¬ 
ing without reaction for a while, suddenly exhibited peculiar 
symptoms and a marked febrile condition, which justified its 
being destroyed. The lesions that were found at the post-mor¬ 
tem were sufficient to explain his condition. He had acute 
pleurisy. The upper part of the lungs displayed also some 
slight peculiar glanderous lesions. 
In March (fourth injection of malleine) there were of the 
six horses remaining some that reacted very slightly, the bal¬ 
ance did not. 
